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HMMER - profile hidden Markov models for biological sequence analysisVersion 2.2 (August 2001)Copyright (C) 1992-2001 Washington University School of Medicine------------------------------------------------------------------o About this software... HMMER is an implementation of profile HMM methods for sensitive database searches using multiple sequence alignments as queries. Basically, you give HMMER a multiple sequence alignment as input; it builds a statistical model called a "hidden Markov model" which you can then use as a query into a sequence database to find (and/or align) additional homologues of the sequence family.o Getting HMMER WWW home: http://hmmer.wustl.edu/ Distribution: ftp://ftp.genetics.wustl.edu/pub/eddy/hmmer/o Installing HMMER See the file INSTALL for brief instructions. See the chapter Installation in the HMMER User's Guide for more detailed instructions. You should also read the following files: COPYING -- copyright notice, and information on the free software license LICENSE -- Full text of the GNU Public License, version 2 (see COPYING) If you have obtained HMMER from Washington University under a non-GPL license as part of a special licensing agreement, COPYING and LICENSE will refer to the terms of that agreement.o Getting started with HMMER The User's Guide is in Userguide/Userguide.pdf [Adobe PDF format]. It is also available online as hypertext: http://hmmer.wustl.edu/hmmer-html/ A quick tutorial intro is given as the first chapter of the User's Guide.o Registering HMMER Email eddy@genetics.wustl.edu to register and get on my infrequent mailing list of HMMER news, patches, and updates.o Reporting bugs These programs are under active development. Though this release has been tested and appears to be stable, bugs may crop up. If you use these programs, please help me out and e-mail me with suggestions, comments, and bug reports. (eddy@genetics.wustl.edu) Sean EddyHoward Hughes Medical Institute and Dept. of Genetics Washington University School of Medicine, St. Louis, Missouri, USA-------------------------------------------------------------------
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