pkinase.slx

hmmer源程序

# ID   pkinase
# AC   PF00069
# DE   Eukaryotic protein kinase domain
# AU   Sonnhammer ELL
# AL   Clustalw
# AM   hmma -qR
# SE   Unknown
# DR   PROSITE; PDOC00100;
# DR   PROSITE; PDOC00212;
# DR   PROSITE; PDOC00213;
# DR   PROSITE; PDOC00629;
# GA   Bic_raw 25 hmmfs 20
# NC   hmmfs 17.60 YPKA_YERPS/2-292
# CC   hmmfs breaks up some members too much, e.g. KS61_MOUSE, which
# CC   hmmls does not.  However, hmmls inserts too many unwelcome insertions.
# **   hmmls fails badly: NINL_DROME gets the whole myosin domain inserted.
# **   Remaking SEED from more seqs only made things worse.
# DR   SCOP; 1apm; sf;
# DR   URL; http://www.sdsc.edu/Kinases/pk_home.html;
# RN   [1]
# RM   92065863
# RA   S.K. Hanks, A.M. Quinn; 
# RL   Methods Enzymol. 200: 38-62 (1991)
# RN   [2]
# RM   95285959
# RA   S.K. Hanks, T. Hunter;
# RL   FASEB J. 9: 576-596 (1995)
# RN   [3]
# RM   97172697
# RA   T. Hunter, G.D. Plowman;
# RL   Trends Biochem. Sci. 22: 18-22 (1997)
# SQ   67
7LES_DROME/2209-2481 LKLLRFLGSGAFGEVYEGQLKTED....SEEPQRVAIKSLRKG.......
ABL1_CAEEL/296-547   IIMHNKLGGGQYGDVYEGYWKR........HDCTIAVKALK.........
ARK1_BOVIN/191-453   FSVHRIIGRGGFGEVYGCRKA........DTGKMYAMKCLD.........
AVR2_HUMAN/192-479   LQLLEVKARGRFGCVWKAQLL..........NEYVAVKIFP.........
BFR2_HUMAN/367-643   LTLGKPLGEGCFGQVVMAEAVGIDK.DKPKEAVTVAVKMLKDDAT.....
BYR1_SCHPO/66-320    LEVVRHLGEGNGGAVSLVKHR..........NIFMARKTVYVG......S
BYR2_SCHPO/394-658   WIRGALIGSGSFGQVYLGMNAS........SGELMAVKQVILD.......
CC15_YEAST/25-272    YHLKQVIGRGSYGVVYKAINK........HTDQVVAIKEVVYE......N
CC21_MEDSA/1-284     GENVEKIGEGTYGVVYKARDR........VTNETIALKKIR........L
CC5_YEAST/82-337     YHRGHFLGEGGFARCFQIKDD.........SGEIFAAKTVA.........
CDPK_SOYBN/34-292    YEVGRKLGQGQFGTTFECTRR........ASGGKFACKSIP.........
CDR1_SCHPO/12-258    WRLGKTLGTGSTSCVRLAKHA........KTGDLAAIKIIP.........
CHK1_SCHPO/10-272    YHIGREIGTGAFASVRLCYDD.........NAKIYAVKFVN........K
CLK1_MOUSE/160-476   YEIVDTLGEGAFGKVVECIDHK.......VGGRRVAVKIVKN.......V
CTK1_YEAST/183-469   YLRIMQVGEGTYGKVYKAKNTN........TEKLVALKKLRLQ.......
ERK1_CANAL/68-371    YQILEIVGEGAYGIVCSAIHK........PSQQKVAIKKIEP.......F
ERK3_HUMAN/20-312    FVDFQPLGFGVNGLVLSAVDS........RACRKVAVKKIALS......D
FUSE_DROME/4-254     YAVSSLVGQGSFGCVYKATRK........DDSKVVAIKVIS.........
HR25_YEAST/9-273     FRIGRKIGSGSFGDIYHGTNL........ISGEEVAIKLES.........
JAK1_HUMAN/571-833   LVQGEHLGRGTRTHIYSGTLMDYKD..DEGTSEEKKIKVIL.........
JAK1_HUMAN/864-1137  LKRIRDLGEGHFGKVELCRYDPED.....NTGEQVAVKSLK.........
KAB7_YEAST/1096-1354 FVSLQKMGEGAYGKVNLCIHK........KNRYIVVIKMIFK.......E
KAKT_MLVAT/171-429   FEYLKLLGKGTFGKVILVKEK........ATGRYYAMKILK.........
KC21_CHICK/39-324    YQLVRKLGRGKYSEVFEAINIT........NNEKVVVKILK.........
KCC4_MOUSE/42-296    FEVESELGRGATSIVYRCKQK........GTQKPYALKVL..........
KCR8_YEAST/316-590   GRCQEVLGKGAFGVVRICQKKNVSSQDGNKSEKLYAVKEFKR........
KG3A_RAT/119-403     YTDIKVIGNGSFGVVYQARLA........ETRELVAIKKVLQ........
KGP1_DROME/457-717   LEVVSTLGIGGFGRVELVKAHH......QDRVDIFALKCLK.........
KI28_YEAST/7-290     YTKEKKVGEGTYAVVYLGCQHS........TGRKIAIKEIK.........
KI82_YEAST/324-602   FEKIRLLGQGDVGKVYLVRER........DTNQIFALKVLN.........
KIN1_SCHPO/125-395   YVLGKTIGAGSMGKVKDAHHL........KTGEQFAIKIVTRLHPDITKA
KIR1_HUMAN/208-495   ITLLECVGKGRYGEVWRGSWQ..........GENVAVKIFS.........
KKIA_HUMAN/5-288     YEKIGKIGEGSYGVVFKCRNR........DTGQIVAIKKFLE........
KKL6_YEAST/192-508   WKKVRPIGSGNFSTVLLYELMDQS....NPKLKQVAVKRLKYPEELSNVE
KMIL_AVIMH/82-339    VLLSTRIGSGSFGTVYKGKWHG........DVAVKILKVVDP.......T
KML2_CHICK/1453-1708 YNIEERLGSGKFGQVFRLVEK........KTGKVWAGKFFK.........
KMOS_CERAE/60-338    VCLLQRLGAGGFGSVYKATYH..........GVPVAIKQVN.........
KPBH_RAT/24-291      YDPKDIIGRGVSSVVRRCVHRA......TGDEFAVKIMEVS.........
KPIM_HUMAN/38-290    YQVGPLLGSGGFGSVYSGIRV........SDNLPVAIKHVE.........
KPK2_PLAFK/111-364   YVLNKKIGKGSFSTAYIGTNI........LYGNRVVVKEVD.........
KPRO_MAIZE/534-812   RKFKVELGRGESGTVYKGVLE.........DDRHVAVKKLEN........
KR1_HSV11/191-478    FTIHGALTPGSEGCVFDSSHP.........DYPQRVIVKA..........
KR1_PRVKA/53-332     FEVLQPLQSGSEGRVFVARRP.........GEADTVVLKV..........
KS61_MOUSE/407-664   YVVKETIGVGSYSVCKRCVHK........ATNMEYAVKVID.........
KYK1_DICDI/1289-1559 LEFGQTIGKGFFGEVKRGYWR..........ETDVAIKIIY.........
KYK2_DICDI/108-364   IQFIQKVGEGAFSEVWEGWWK..........GIHVAIKKLKIIG.....D
MAK_RAT/4-284        YTTMRQLGDGTYGSVLMGKSN........ESGELVAIKRMK.........
MEK1_YEAST/162-444   EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK.........
MET_HUMAN/1078-1337  VHFNEVIGRGHFGCVYHGTLLDND.....GKKIHCAVKSLN.........
MKK1_YEAST/221-488   IETLGILGEGAGGSVSKCKLK........NGSKIFALKVIN.........
MLK1_HUMAN/3-262     LTLEEIIGIGGFGKVYRAFWI..........GDEVAVKAARHD......P
NINL_DROME/16-282    FEIYEEIAQGVNAKVFRAKELD........NDRIVALKIQHYD......E
NPR1_YEAST/438-742   IKTGADLGAGAGGSVKLAQRIS........DNKIFAVKEFR........T
PHY_CERPU/1004-1282  IQITGSLGSGSSATVEKAVWL..........GTPVAKKTFYG........
PKD1_DICDI/36-291    FNFYGSLGSGSFGTAKLCRHR........GSGLFFCSKTLR.........
PKN1_MYXXA/59-321    FRLVRRLGRGGMGAVYLGEHVS........IGSRVAVKVLH.........
RAN1_SCHPO/18-295    LRFVSIIGAGAYGVVYKAEDIY........DGTLYAVKALC.........
RYK_HUMAN/327-593    ITLKDVLQEGTFGRIFHGILIDEKD...PNKEKQAFVKTVKD.......Q
SGV1_YEAST/60-366    YREDEKLGQGTFGEVYKGIHL........ETQRQVAMKKIIVS......V
SPK1_YEAST/198-466   SIIDEVVGQGAFATVKKAIER........TTGKTFAVKIIS.........
ST20_YEAST/620-871   YANLVKIGQGASGGVYTAYEIG........TNVSVAIKQMNLE.......
STE7_YEAST/191-466   LVQLGKIGAGNSGTVVKALHVP........DSKIVAKKTIP........V
SYK_PIG/364-619      TLEDKELGSGNFGTVKKGYYQMK......KVVKTVAVKILKN........
TOP_DROME/938-1194   LRKGGVLGMGAFGRVYKGVWVPEG....ENVKIPVAIKELLKSTG.....
TRKA_HUMAN/504-775   IVLKWELGEGAFGKVFLAECHNLLP...EQDKMLVAVKALK.........
TTK_HUMAN/509-775    YSILKQIGSGGSSKVFQVLNE.........KKQIYAIKYVN........L
WEE1_HUMAN/299-569   FHELEKIGSGEFGSVFKCVKR........LDGCIYAIKRS..........

7LES_DROME/2209-2481 ASEFAE............LLQEAQLMSNFK......HENIVRLVGICF..
ABL1_CAEEL/296-547   EDAMPLH..........EFLAEAAIMKDLH......HKNLVRLLGVCT..
ARK1_BOVIN/191-453   KKRIKMKQGE......TLALNERIMLSLVSTG...DCPFIVCMSYAFH..
AVR2_HUMAN/192-479   IQDKQS..........WQNEYEVYSLPGMK......HENILQFIGAEKRG
BFR2_HUMAN/367-643   EKDLSD............LVSEMEMMKMIG.....KHKNIINLLGACTQ.
BYR1_SCHPO/66-320    DSKLQK...........QILRELGVLHHCR......SPYIVGFYGAFQ..
BYR2_SCHPO/394-658   SVSESKDRHAKLL...DALAGEIALLQELS......HEHIVQYLGSNL..
CC15_YEAST/25-272    DEELN............DIMAEISLLKNLN......HNNIVKYHGFIR..
CC21_MEDSA/1-284     EQEDEG.....VP...STAIREISLLKEMQ......HRNIVRLQDVVH..
CC5_YEAST/82-337     KASIK...SEKTR...KKLLSEIQIHKSMS......HPNIVQFIDCFE..
CDPK_SOYBN/34-292    KRKLLCKEDYED......VWREIQIMHHLSE.....HANVVRIEGTYE..
CDR1_SCHPO/12-258    IRYAS.............IGMEILMMRLLR......HPNILRLYDVWT..
CHK1_SCHPO/10-272    KHATSCMNAGVWA...RRMASEIQLHKLCNG.....HKNIIHFYNTAE..
CLK1_MOUSE/160-476   DRYCEA............AQSEIQVLEHLNTTDP..HSTFRCVQMLEWF.
CTK1_YEAST/183-469   GEREG......FP...ITSIREIKLLQSFD......HPNVSTIKEIMVE.
ERK1_CANAL/68-371    ERSMLCLR..........TLRELKLLKHFN......HENIISILAIQRPI
ERK3_HUMAN/20-312    ARSMKH............ALREIKIIRRLD......HDNIVKVYEVLGPK
FUSE_DROME/4-254     KRGRATKELKN.......LRRECDIQARLK......HPHVIEMIESFE..
HR25_YEAST/9-273     IRSRHP...........QLDYESRVYRYLS......GGVGIPFIRWFGR.
JAK1_HUMAN/571-833   KVLDPSHRDIS.....LAFFEAASMMRQVS......HKHIVYLYGVCV..
JAK1_HUMAN/864-1137  PESGGN........HIADLKKEIEILRNLY......HENIVKYKGICTED
KAB7_YEAST/1096-1354 RILVDTWVRDRKL...GTIPSEIQIMATLNKK...PHENILRLLDFFE..
KAKT_MLVAT/171-429   KEVIVAKDEVAH......TLTENRVLQNSR......HPFLTALKYSFQ..
KC21_CHICK/39-324    PVKKKK............IKREIKILENLRG.....GPNIITLADIVKDP
KCC4_MOUSE/42-296    KKTVD....KKI......VRTEIGVLLRLS......HPNIIKLKEIFE..
KCR8_YEAST/316-590   RTSESAEKYSKR......LTSEFCISSSLH......HTNIVTTLDLFQD.
KG3A_RAT/119-403     DKRFK..............NRELQIMRKLD......HCNIVRLRYFFYSS
KGP1_DROME/457-717   KRHIVDTKQEE......HIFSERHIMLSSR......SPFICRLYRTFR..
KI28_YEAST/7-290     TSEFKDGLDMS.......AIREVKYLQEMQ......HPNVIELIDIFM..
KI82_YEAST/324-602   KHEMIK...RKKI...KRVLTEQEILATSD......HPFIVTLYHSFQ..
KIN1_SCHPO/125-395   KAAASAEATKAAQ...SEKNKEIRTVREAALSTLLRHPYICEARDVYI..
KIR1_HUMAN/208-495   SRDEKS............WFRETELYNTVMLR....HENILGFIASDMTS
KKIA_HUMAN/5-288     SEDDP.....VIK...KIALREIRMLKQLK......HPNLVNLLEVFR..
KKL6_YEAST/192-508   QINTSLRYKETLSRLENSLTRELQVLKSLN......HPCIVKLLGINNPI
KMIL_AVIMH/82-339    PEQFQA............FRNEVAVLRKTR......HVNILLFMGYMT..
KML2_CHICK/1453-1708 AYSAK...EKEN......IRDEISIMNCLH......HPKLVQCVDAFE..
KMOS_CERAE/60-338    KCTKNRLASRR.......SFWAELNVARLR......HDNIVRVVAASTRT
KPBH_RAT/24-291      AERLSLEQLEEVR...DATRREMHILRQVAG.....HPHIITLIDSYE..
KPIM_HUMAN/38-290    KDRISDWGELPNG...TRVPMEVVLLKKVSSG....FSGVIRLLDWFE..
KPK2_PLAFK/111-364   KSKVK....ESN......VYTEIEVLRKVM......HKYIIKLISAYE..
KPRO_MAIZE/534-812   VRQGKE...........VFQAELSVIGRIN......HMNLVRIWGFCS..
KR1_HSV11/191-478    GWYTS.............TSHEARLLRRLD......HPAILPLLDLHV..
KR1_PRVKA/53-332     GQKPS.............TLMEGMLLQRLS......HDNVMRMKQMLA..
KS61_MOUSE/407-664   KSKRD.............PSEEIEILLRYGQ.....HPNIITLKDVYD..
KYK1_DICDI/1289-1559 RDQFKT...KSSL...VMFQNEVGILSKLR......HPNVVQFLGACTAG
KYK2_DICDI/108-364   EEQFKER...........FIREVQNLKKGN......HQNIVMFIGACY..
MAK_RAT/4-284        RKFYSWDECMN........LREVKSLKKLN......HANVIKLKEVIR..
MEK1_YEAST/162-444   LKPNK.............FDKEARILLRLD......HPNIIKVYHTFCD.
MET_HUMAN/1078-1337  RITDIGEVS........QFLTEGIIMKDFS......HPNVLSLLGICLR.
MKK1_YEAST/221-488   TLNTDPEYQKQ.......IFRELQFNRSFQ......SEYIVRYYGMFTDD
MLK1_HUMAN/3-262     DEDISQTIEN........VRQEAKLFAMLK......HPNIIALRGVCL..
NINL_DROME/16-282    EHQVS.............IEEEYRTLRDYCD.....HPNLPEFYGVYKLS
NPR1_YEAST/438-742   KFENES..KRDYV...KKITSEYCIGTTLN......HPNIIETIEIVY..
PHY_CERPU/1004-1282  RNNED.............FKREVEILAELC......HPNITSMFCSPL..
PKD1_DICDI/36-291    RETIVHEKHKEH......VNNEINIMLNIS......HPYIVKTYSTFN..
PKN1_MYXXA/59-321    AHLTMYPELVQR......FHAEARAVNLIG......HENIVSIFDMDA..
RAN1_SCHPO/18-295    KDGLNEKQKK.......LQARELALHARVSS.....HPYIITLHRVLE..
RYK_HUMAN/327-593    ASEIQVT..........MMLTESCKLRGLH......HRNLLPITHVCIE.
SGV1_YEAST/60-366    EKDLFP..........ITAQREITILKRLN......HKNIIKLIEMVYDH
SPK1_YEAST/198-466   KRKVIGNMDG........VTRELEVLQKLN......HPRIVRLKGFYE..
ST20_YEAST/620-871   KQPKKE...........LIINEILVMKGSK......HPNIVNFIDSYV..
STE7_YEAST/191-466   EQNNS.....TII...NQLVRELSIVKNVKP.....HENIITFYGAYYN.
SYK_PIG/364-619      EANDPALKD........ELLAEANVMQQLD......NPYIVRMIGICE..
TOP_DROME/938-1194   AESSEE............FLREAYIMASEE......HVNLLKLLAVCM..
TRKA_HUMAN/504-775   EASESAR.........QDFQREAELLTMLQ......HQHIVRFFGVCTE.
TTK_HUMAN/509-775    EEADNQTLDS........YRNEIAYLNKLQQH....SDKIIRLYDYEI..
WEE1_HUMAN/299-569   KKPLAGSVDEQN......ALREVYAHAVLGQ.....HSHVVRYFSAWA..

7LES_DROME/2209-2481 .................DTESISLIMEHMEAG......DLLSYLRAARAT
ABL1_CAEEL/296-547   .................HEAPFYIITEFMCNG......NLLEYLRRTDKS
ARK1_BOVIN/191-453   .................TPDKLSFILDLMNGG......DLHYHLSQHG..
AVR2_HUMAN/192-479   ...............TSVDVDLWLITAFHEKG......SLSDFLKANV..
BFR2_HUMAN/367-643   ..................DGPLYVIVEYASKG......NLREYLRARRPP
BYR1_SCHPO/66-320    .................YKNNISLCMEYMDCG......SLDAILREGG..
BYR2_SCHPO/394-658   .................NSDHLNIFLEYVPGG......SVAGLLTMYG..
CC15_YEAST/25-272    .................KSYELYILLEYCANG......SLRRLISRSS..
CC21_MEDSA/1-284     .................SDKRLYLVFEYLDL.......DLKKHMDSSPE.
CC5_YEAST/82-337     .................DDSNVYILLEICPNG......SLMELLKRRK..
CDPK_SOYBN/34-292    .................DSTAVHLVMELCEGG......ELFDRIVQKG..