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<td colspan="2" bgcolor="FFE3F3"> 更新时间:2008-6-18 20:34:22 【字体:<a href="javascript:fontZoomA();" class="top_UserLogin">小</a> <a href="javascript:fontZoomB();" class="top_UserLogin">大</a>】</td>
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<div> 在我国乳腺癌已成为威胁女性健康的主要杀手。虽然乳腺癌总体愈后较好,但治疗不规范,反而会给病人带来巨大的副作用及不必要的经济负担,甚至破坏正常免疫力、诱发肿瘤耐药而加速肿瘤发展。由于肿瘤在手术前即有全身性微小转移,现在治疗的重点已从乳腺广泛切除转为局部切除,全身性治疗如化疗和内分泌治疗的应用也越来越多。<br />
内分泌治疗现已广泛用于乳腺癌治疗的各阶段,既可单用也可与化疗合并使用。目前最常用的内分泌药物是三苯氧胺,它疗效肯定,使用方便,但长期用药容易产生耐药及肝、视网膜毒性,尤其是会诱发子宫内膜癌。三苯氧胺无效者或担心其副作用者虽可改用其它类型的内分泌药物,如氨鲁米特、孕激素等。但它们在疗效或耐受性方面都不够理想,临床使用也受到限制,因此临床迫切需要一个作用机理独特、疗效与安全性俱佳的药物,在三苯氧胺不宜使用时作为替代。</div>
<div> 兰他隆(Lentaron),就是这样一种新型乳腺癌治疗药物。兰他隆特异的结构可以与雌激素生成的关键酶——芳香化酶发生不可逆的结合并使其失去活性,从而阻断雌激素生成并大大降低体内雌激素水平。由于雌激素是乳腺最重要的促分裂因子,缺乏雌激素将使癌细胞的生长停止,使肿瘤缩小,病人症状改善,从而达到治疗目的。</div>
<div> 兰他隆的作用机理不同于现有的乳腺癌治疗药物,与它们没有交叉耐药,因此即使在其它治疗方法失败后仍可能起效,与化疗协同使用还可进一步提高疗效并延缓肿瘤复发。作为新一代的芳香化酶抑制剂,兰他隆不干扰醛固酮和可的松代谢,不需要加激素;临床试验表明:对复发病人单有兰他隆,客观缓解率17%~26%,病情稳定率20%~30%,平均缓解时间13~33个月。而且兰他隆治疗取得病情稳定者,其生存时间也接近于取得完全缓解者。动物试验还证实:兰他隆可预防78%的乳腺癌发生,降低乳腺癌死亡率83%。</div>
<div> 兰他隆与其它内分泌药物相比,不仅在有效率、缓解时间、总生存时间等指标上有提高,而且副作用显著减少,适合体质较差和伴有高血压、糖尿病或心功能不良者长期使用。 </div>
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<td width="787"><li>上一篇文章: <a class='LinkPrevArticle' href='/Article/943.html' title='文章标题:如何选择乳腺癌手术时间
作 者:admin
更新时间:2008-6-18 20:34:22'>如何选择乳腺癌手术时间</a></li><br>
<li>下一篇文章: <a class='LinkNextArticle' href='/Article/945.html' title='文章标题:锻炼有益治疗乳腺癌
作 者:admin
更新时间:2008-6-18 20:34:22'>锻炼有益治疗乳腺癌</a></li></td>
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毛舜英<br>
主任医师</p>
<p> 上海市妇女康复专业委员会委员,农工民主党党员,曾先后担任浙医大妇幼保健院妇产科医师、湖州市中心医院妇产科主任、湖州市第二届计划生育协会副会长,现任湖州阳光女子医院名誉院长、妇科主任。</p></td>
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