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HEADER LYASE/LYASE/SIGNALING PROTEIN 16-AUG-99 1CS4 TITLE COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN TITLE 2 ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'- TITLE 3 MONOPHOSPHATE, PYROPHOSPHATE AND MG COMPND MOL_ID: 1; COMPND 2 MOLECULE: TYPE V ADENYLATE CYCLASE; SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: CANIS FAMILIARIS; KEYWDS COMPLEX (LYASE/HYDROLASE), HYDROLASE, SIGNAL TRANSDUCING KEYWDS 2 PROTEIN, CYCLASE, EFFECTOR ENZYME, LYASE/HYDROLASE COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR J.J.G.TESMER,C.A.DESSAUER,R.K.SUNAHARA,R.A.JOHNSON, AUTHOR 2 A.G.GILMAN,S.R.SPRANG REVDAT 2 21-MAR-01 1CS4 3 HETATM REMARK REVDAT 1 10-JAN-01 1CS4 0 JRNL AUTH J.J.G.TESMER,C.A.DESSAUER,R.K.SUNAHARA,L.D.MURRAY, JRNL AUTH 2 R.A.JOHNSON,A.G.GILMAN,S.R.SPRANG JRNL TITL MOLECULAR BASIS FOR P-SITE INHIBITION OF ADENYLYL JRNL TITL 2 CYCLASE JRNL REF BIOCHEMISTRY V. 39 14464 2000 JRNL REFN ASTM BICHAW US ISSN 0006-2960 REMARK 1 REMARK 1 REFERENCE 1 REMARK 1 AUTH J.J.G.TESMER,R.K.SUNAHARA,A.G.GILMAN,S.R.SPRANG REMARK 1 TITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAINS OF REMARK 1 TITL 2 ADENYLYL CYCLASE IN A COMPLEX WITH REMARK 1 TITL 3 GS(ALPHA)-GTP(GAMMA)S REMARK 1 REF SCIENCE V. 278 1907 1997 REMARK 1 REFN ASTM SCIEAS US ISSN 0036-8075 REMARK 2 REMARK 2 RESOLUTION. 2.50 ANGSTROMS. REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 1CUL RELATED DB: PDB DBREF 1CS4 A 363 580 SWS P30803 CYA5_CANFA 363 580 DBREF 1CS4 B 870 1081 SWS P26769 CYA2_RAT 870 1081 DBREF 1CS4 C 1 394 SWS P04896 GBAS_BOVIN 1 394 SEQADV 1CS4 MET A 476 SWS P30803 VAL 476 ENGINEERED SEQRES 4 A 225 ALA ASP ILE GLU GLY PHE THR SER LEU ALA SER GLN CYS SEQRES 5 A 225 THR ALA GLN GLU LEU VAL MET THR LEU ASN GLU LEU PHE SEQRES 6 A 225 ALA ARG PHE ASP LYS LEU ALA ALA GLU ASN HIS CYS LEU SEQRES 7 A 225 ARG ILE LYS ILE LEU GLY ASP CYS TYR TYR CYS VAL SER HET MG 396 1 HET MG 397 1 HET CL 398 1 HET GSP 1000 32 HET 101 1001 22 HET FOK 1002 29 HET MES 1003 12 HET MES 1004 12 HET POP 1005 9 HETNAM MG MAGNESIUM ION HETNAM CL CHLORIDE ION HETNAM GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE HETNAM 101 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE HETNAM FOK FORSKOLIN HETNAM MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID HETNAM POP PYROPHOSPHATE 2- FORMUL 4 MG 2(MG1 2+) FORMUL 6 CL CL1 1- FORMUL 7 GSP C10 H16 N5 O13 P3 S1 FORMUL 8 101 C10 H14 N5 O6 P1 FORMUL 9 FOK C22 H34 O7 FORMUL 10 MES 2(C6 H13 N1 O4 S1) FORMUL 12 POP H2 O7 P2 2- FORMUL 13 HOH *77(H2 O1) HELIX 1 1 GLY A 399 SER A 405 1 7 HELIX 2 2 THR A 408 ASN A 430 1 23 SHEET 1 A 5 LEU A 433 LEU A 438 0 SHEET 3 A 5 ILE A 384 ILE A 397 -1 N SER A 391 O SER A 446 SHEET 1 A1 7 LEU A 433 LEU A 438 0 SHEET 3 A1 7 ILE A 384 ILE A 397 -1 N SER A 391 O SER A 446 ATOM 164 N ASP A 396 51.711 -11.782 62.798 1.00 51.17 N ATOM 165 CA ASP A 396 52.810 -11.644 61.848 1.00 54.45 C ATOM 166 C ASP A 396 54.137 -11.314 62.530 1.00 55.11 C ATOM 167 O ASP A 396 54.175 -10.524 63.469 1.00 55.34 O ATOM 168 CB ASP A 396 52.437 -10.555 60.831 1.00 57.50 C ATOM 169 CG ASP A 396 53.460 -10.391 59.729 1.00 61.38 C ATOM 170 OD1 ASP A 396 54.316 -9.485 59.841 1.00 65.55 O ATOM 171 OD2 ASP A 396 53.390 -11.146 58.736 1.00 63.68 O ATOM 172 N ILE A 397 55.216 -11.941 62.066 1.00 57.14 N ATOM 173 CA ILE A 397 56.546 -11.705 62.624 1.00 59.46 C ATOM 174 C ILE A 397 57.020 -10.305 62.230 1.00 60.12 C ATOM 175 O ILE A 397 56.963 -9.927 61.060 1.00 59.12 O ATOM 176 CB ILE A 397 57.583 -12.722 62.094 1.00 60.84 C ATOM 177 CG1 ILE A 397 57.184 -14.163 62.447 1.00 63.12 C ATOM 178 CG2 ILE A 397 58.975 -12.384 62.632 1.00 61.24 C ATOM 179 CD1 ILE A 397 57.408 -14.554 63.895 1.00 63.92 C ATOM 180 N GLU A 398 57.492 -9.548 63.212 1.00 60.23 N ATOM 181 CA GLU A 398 57.975 -8.198 62.971 1.00 62.14 C ATOM 182 C GLU A 398 59.401 -8.277 62.424 1.00 60.59 C ATOM 183 O GLU A 398 60.244 -8.972 62.987 1.00 61.84 O ATOM 184 CB GLU A 398 57.917 -7.386 64.272 1.00 65.47 C ATOM 185 CG GLU A 398 58.037 -5.874 64.091 1.00 70.25 C ATOM 186 CD GLU A 398 57.588 -5.089 65.324 1.00 72.94 C ATOM 187 OE1 GLU A 398 58.262 -5.175 66.377 1.00 70.76 O ATOM 188 OE2 GLU A 398 56.555 -4.380 65.232 1.00 74.36 O ATOM 189 N GLY A 399 59.642 -7.608 61.298 1.00 57.58 N ATOM 190 CA GLY A 399 60.956 -7.615 60.681 1.00 56.14 C ATOM 191 C GLY A 399 61.452 -8.993 60.265 1.00 58.03 C ATOM 192 O GLY A 399 62.620 -9.322 60.480 1.00 57.47 O ATOM 193 N PHE A 400 60.576 -9.789 59.649 1.00 58.00 N ATOM 194 CA PHE A 400 60.914 -11.143 59.200 1.00 58.07 C ATOM 195 C PHE A 400 61.995 -11.219 58.117 1.00 58.57 C ATOM 196 O PHE A 400 62.862 -12.091 58.161 1.00 59.44 O ATOM 197 CB PHE A 400 59.657 -11.881 58.734 1.00 59.18 C ATOM 198 CG PHE A 400 59.900 -13.316 58.322 1.00 58.53 C ATOM 199 CD1 PHE A 400 60.377 -14.251 59.237 1.00 57.59 C ATOM 200 CD2 PHE A 400 59.613 -13.736 57.024 1.00 57.95 C ATOM 201 CE1 PHE A 400 60.557 -15.583 58.864 1.00 59.98 C ATOM 202 CE2 PHE A 400 59.790 -15.063 56.643 1.00 58.52 C ATOM 203 CZ PHE A 400 60.261 -15.990 57.563 1.00 58.10 C ATOM 204 N THR A 401 61.921 -10.341 57.123 1.00 58.08 N ATOM 205 CA THR A 401 62.916 -10.337 56.055 1.00 56.79 C ATOM 206 C THR A 401 64.304 -10.010 56.634 1.00 57.24 C ATOM 207 O THR A 401 65.320 -10.547 56.187 1.00 55.16 O ATOM 208 CB THR A 401 62.528 -9.348 54.936 1.00 55.59 C ATOM 209 OG1 THR A 401 61.204 -9.650 54.473 1.00 54.91 O ATOM 210 CG2 THR A 401 63.495 -9.452 53.764 1.00 53.04 C ATOM 211 N SER A 402 64.323 -9.169 57.667 1.00 56.99 N ATOM 212 CA SER A 402 65.558 -8.772 58.342 1.00 58.09 C ATOM 213 C SER A 402 66.138 -9.957 59.121 1.00 59.79 C ATOM 214 O SER A 402 67.341 -10.241 59.058 1.00 58.14 O ATOM 215 CB SER A 402 65.260 -7.617 59.306 1.00 58.37 C ATOM 216 OG SER A 402 66.421 -7.159 59.974 1.00 55.94 O ATOM 217 N LEU A 403 65.253 -10.655 59.828 1.00 60.85 N ATOM 218 CA LEU A 403 65.598 -11.807 60.650 1.00 61.09 C ATOM 219 C LEU A 403 66.147 -12.991 59.843 1.00 62.81 C ATOM 220 O LEU A 403 67.235 -13.495 60.131 1.00 61.33 O ATOM 221 CB LEU A 403 64.370 -12.220 61.457 1.00 60.24 C ATOM 222 CG LEU A 403 64.530 -13.262 62.555 1.00 63.33 C ATOM 223 CD1 LEU A 403 65.692 -12.895 63.470 1.00 65.31 C ATOM 224 CD2 LEU A 403 63.232 -13.353 63.340 1.00 64.51 C ATOM 225 N ALA A 404 65.398 -13.415 58.826 1.00 65.20 N ATOM 226 CA ALA A 404 65.787 -14.532 57.960 1.00 68.38 C ATOM 227 C ALA A 404 67.007 -14.213 57.094 1.00 70.82 C ATOM 228 O ALA A 404 67.607 -15.105 56.479 1.00 71.80 O ATOM 229 CB ALA A 404 64.616 -14.944 57.079 1.00 66.92 C ATOM 230 N SER A 405 67.354 -12.932 57.042 1.00 72.71 N ATOM 231 CA SER A 405 68.485 -12.447 56.265 1.00 73.57 C ATOM 232 C SER A 405 69.791 -12.628 57.045 1.00 75.23 C ATOM 233 O SER A 405 70.878 -12.568 56.467 1.00 76.00 O ATOM 234 CB SER A 405 68.265 -10.966 55.936 1.00 72.32 C ATOM 235 OG SER A 405 69.156 -10.499 54.945 1.00 70.40 O ATOM 236 N GLN A 406 69.675 -12.875 58.350 1.00 76.83 N ATOM 237 CA GLN A 406 70.837 -13.048 59.223 1.00 78.12 C ATOM 238 C GLN A 406 71.259 -14.494 59.465 1.00 80.42 C ATOM 239 O GLN A 406 72.391 -14.881 59.145 1.00 81.68 O ATOM 240 CB GLN A 406 70.597 -12.354 60.557 1.00 75.97 C ATOM 241 CG GLN A 406 70.317 -10.879 60.416 1.00 78.05 C ATOM 242 CD GLN A 406 70.140 -10.212 61.750 1.00 78.52 C ATOM 243 OE1 GLN A 406 71.102 -10.029 62.490 1.00 78.65 O ATOM 244 NE2 GLN A 406 68.902 -9.859 62.080 1.00 81.68 N ATOM 245 N CYS A 407 70.360 -15.280 60.051 1.00 81.23 N ATOM 246 CA CYS A 407 70.641 -16.682 60.341 1.00 81.90 C ATOM 247 C CYS A 407 70.484 -17.589 59.118 1.00 80.94 C ATOM 248 O CYS A 407 69.924 -17.187 58.095 1.00 79.51 O ATOM 249 CB CYS A 407 69.767 -17.180 61.498 1.00 83.37 C ATOM 250 SG CYS A 407 67.992 -17.169 61.165 1.00 84.69 S ATOM 251 N THR A 408 70.999 -18.811 59.236 1.00 80.19 N ATOM 252 CA THR A 408 70.929 -19.796 58.161 1.00 79.55 C ATOM 253 C THR A 408 69.486 -20.243 57.912 1.00 78.78 C ATOM 254 O THR A 408 68.644 -20.148 58.803 1.00 78.45 O ATOM 255 CB THR A 408 71.833 -21.015 58.462 1.00 79.73 C ATOM 256 OG1 THR A 408 71.645 -22.019 57.457 1.00 81.02 O ATOM 257 CG2 THR A 408 71.529 -21.596 59.844 1.00 79.82 C ATOM 258 N ALA A 409 69.200 -20.711 56.699 1.00 77.92 N ATOM 259 CA ALA A 409 67.852 -21.159 56.345 1.00 77.59 C ATOM 260 C ALA A 409 67.379 -22.335 57.200 1.00 78.55 C ATOM 261 O ALA A 409 66.180 -22.525 57.402 1.00 79.07 O ATOM 262 CB ALA A 409 67.782 -21.510 54.870 1.00 77.63 C ATOM 263 N GLN A 410 68.334 -23.115 57.700 1.00 79.69 N ATOM 264 CA GLN A 410 68.060 -24.276 58.545 1.00 79.08 C ATOM 265 C GLN A 410 67.537 -23.818 59.908 1.00 77.23 C ATOM 266 O GLN A 410 66.458 -24.222 60.329 1.00 76.62 O ATOM 267 CB GLN A 410 69.348 -25.102 58.711 1.00 82.32 C ATOM 268 CG GLN A 410 69.228 -26.383 59.543 1.00 84.09 C ATOM 269 CD GLN A 410 70.580 -27.067 59.772 1.00 88.07 C ATOM 270 OE1 GLN A 410 71.637 -26.497 59.490 1.00 87.61 O ATOM 271 NE2 GLN A 410 70.548 -28.292 60.291 1.00 88.14 N ATOM 272 N GLU A 411 68.299 -22.945 60.565 1.00 76.61 N ATOM 273 CA GLU A 411 67.958 -22.399 61.881 1.00 75.61 C ATOM 274 C GLU A 411 66.599 -21.695 61.903 1.00 72.48 C ATOM 275 O GLU A 411 65.829 -21.860 62.850 1.00 70.94 O ATOM 276 CB GLU A 411 69.059 -21.429 62.325 1.00 80.11 C ⌨️ 快捷键说明
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