sc_to_e.c

序列对齐 Compare a protein sequence to a protein sequence database or a DNA sequence to a DNA sequenc

/* copyright (c) 1996, 1997, 1998, 1999 William R. Pearson and the
   U. of Virginia */

/* $Name: fa35_03_06 $ - $Id: sc_to_e.c,v 1.2 2006/04/12 18:00:02 wrp Exp $ */

/* sc_to_e  uses statistical parameters from search and
	    score, length, and database size to calculate E()
*/

#include <stdio.h>
#include <stdlib.h>
#include <math.h>

double mean_var, mu, rho;

main(argc, argv)
     int argc; char **argv;
{
  char line[128];
  int score, length, db_size;
  double z_val, s_to_zv(), zv_to_E();

  if (argc == 4) {
    sscanf(argv[1],"%lf",&rho);
    sscanf(argv[2],"%lf",&mu);
    sscanf(argv[3],"%lf",&mean_var);
  }
  else {
    fprintf(stderr," enter rho mu mean_var: ");
    fgets(line,sizeof(line),stdin);
    sscanf(line,"%lf %lf %lf",&rho, &mu, &mean_var);
  }

  while (1) {
    fprintf(stderr," enter score length db_size: ");
    if (fgets(line,sizeof(line),stdin)==NULL) exit(0);
    if (line[0]=='\n') exit(0);
    sscanf(line,"%d %d %d",&score, &length, &db_size);
    if (db_size < 1) db_size = 50000;

    z_val = s_to_zv(score, length);

    printf(" s: %d (%d) E(%d): %4.2g\n",score,length,db_size,zv_to_E(z_val,db_size));
  }
}

double s_to_zv(int score, int length)
{
  return ((double)score - rho * log((double)length) - mu)/sqrt(mean_var);
}

double zv_to_E(double zv, int db_size)
{
  double e;

  e = exp(-1.282554983 * zv - .577216);
  return (double)db_size * (e > .01 ? 1.0 - exp(-e) : e);
}