pksumm.hlp

是一个经济学管理应用软件 很难找的 但是经济学学生又必须用到

{smcl}
{* 08mar2005}{...}
{cmd:help pksumm}{right:dialog:  {bf:{dialog pksumm}}}
{hline}

{title:Title}

{p2colset 5 19 21 2}{...}
{p2col :{hi:[R] pksumm} {hline 2}}Summarize pharmacokinetic data{p_end}
{p2colreset}{...}


{title:Syntax}

{p 8 15 2}
{cmd:pksumm} {it:id time concentration} {ifin} [{cmd:,} {it:options}]

{synoptset 20 tabbed}{...}
{synopthdr}
{synoptline}
{syntab :Main}
{synopt :{opt t:rapezoid}}use trapezoidal rule to calculate AUC; default is
cubic splines{p_end}
{synopt :{opt fit(#)}}use {it:#} points to estimate AUC; default is
{cmd:fit(3)}{p_end}
{synopt :{opt notime:chk}}do not check whether follow-up time for all subjects
is the same{p_end}
{synopt :{opt nod:ots}}suppress the dots during calculation{p_end}
{synopt :{opt g:raph}}graph the distribution of {it:statistic}{p_end}
{synopt :{opt stat(statistic)}}graph the specified statistic; default is
{cmd:stat(auc)}{p_end}

{syntab :Histogram, Density plots, Y-Axis, X-Axis, Title, Caption, Legend, Overall}
{synopt :{it:histogram_options}}any of the options allowed with 
{helpb histogram}{p_end}
{synoptline}
{p2colreset}{...}

{synoptset 20}{...}
{marker statistic}
{synopthdr :statistic}
{synoptline}
{synopt :{opt auc}}area under the concentration-time curve (AUC); the default{p_end}
{synopt :{opt aucline}}area under the concentration-time curve
from 0 to infinity using a linear extension{p_end}
{synopt :{opt aucexp}}area under the concentration-time curve from
0 to infinity using an exponential extension{p_end}
{synopt :{opt auclog}}area under the log-concentration-time curve
extended with a linear fit{p_end}
{synopt :{opt half}}half-life of the drug{p_end}
{synopt :{opt ke}}elimination rate{p_end}
{synopt :{opt cmax}}maximum concentration{p_end}
{synopt :{opt tmax}}time at last concentration{p_end}
{synopt :{opt tomc}}time of maximum concentration{p_end}
{synoptline}
{p2colreset}{...}


{title:Description}

{pstd}
{cmd:pksumm} obtains summary measures based on the first four moments from the
empirical distribution of each pharmacokinetic measurement and tests the null
hypothesis that the distribution of that measurement is normally distributed.

{pstd}
{cmd:pksumm} is one of the pk commands.  Please read {helpb pk} before reading
this entry.


{title:Options}

{dlgtab:Main}

{phang}
{opt trapezoid} specifies that the trapezoidal rule be used to calculate
the AUC.  The default is cubic splines, which give better results for most
situations.  In cases where the curve is very irregular, the trapezoidal
rule may give better results.

{phang}
{opt fit(#)} specifies the number of points, counting back from the last time
measurement, to use in fitting the extension to estimate the AUC.  The default
is {cmd:fit(3)}, the last 3 points.  This should be viewed as a minimum; the
appropriate number of points will depend on the data.

{phang}
{opt notimechk} suppresses the check that the follow-up time for all subjects
is the same.  By default, {cmd:pksumm} expects the maximum follow-up time to
be equal for all subjects.

{phang}
{opt nodots} suppresses the progress dots during calculation.  By default, a
period is displayed for every call to calculate the pharmacokinetic measures.

{phang}
{opt graph} requests a graph of the distribution of the statistic specified
with {opt stat()}.

{phang}
{opt stat(statistic)} specifies the statistic that {cmd:pksumm} should graph.
The default is {cmd:stat(auc)}.  If the {opt graph} option is not specified,
this option is ignored.

{dlgtab:Histogram, Density plots, ...}

{phang}
{it:histogram_options} are any of the options allowed with {helpb histogram}.
Note that for {cmd:pksumm}, {cmd:fraction} is the default, rather than
{cmd:density}.


{title:Remarks}

{pstd}
{cmd:pksumm} produces summary statistics for the distribution of nine
common pharmacokinetic measurements.  If there are more than eight subjects,
{cmd:pksumm} also computes a test for normality on each measurement.
The nine measurements summarized by {cmd:pksumm} are listed 
{help pksumm##statistic:above}.


{title:Examples}

{phang}{cmd:. pksumm id time conc}{p_end}

{phang}{cmd:. pksumm id time conc, graph bin(20)}{p_end}

{phang}{cmd:. pksumm id time conc, stat(auclog) graph bin(20)}


{title:Also see}

{psee}
Manual:  {bf:[R] pksumm}

{psee}
Online:  {helpb pk}, {helpb pkcollapse}, {helpb pkcross},
{helpb pkequiv}, {helpb pkexamine}, {helpb pkshape}
{p_end}