pkexamine.hlp

是一个经济学管理应用软件 很难找的 但是经济学学生又必须用到

{smcl}
{* 06mar2005}{...}
{cmd:help pkexamine}{right:dialog:  {bf:{dialog pkexamine}}}
{hline}

{title:Title}

{p2colset 5 22 24 2}{...}
{p2col :{hi:[R] pkexamine} {hline 2}}Calculate pharmacokinetic measures{p_end}
{p2colreset}{...}


{title:Syntax}

{p 8 18 2}
{cmd:pkexamine} {it:time concentration} {ifin} [{cmd:,} {it:options}]

{synoptset 19 tabbed}{...}
{synopthdr}
{synoptline}
{syntab :Main}
{synopt :{opt t:rapezoid}}use trapezoidal rule; default is cubic splines{p_end}
{synopt :{opt fit(#)}}use {it:#} points to estimate AUC; default is
{cmd:fit(3)}{p_end}
{synopt :{opt g:raph}}graph the AUC{p_end}
{synopt :{opt line}}graph the linear extension{p_end}
{synopt :{opt log}}graph the log extension{p_end}
{synopt :{opt exp(#)}}plot the exponential fit for the AUC (0 to infinity){p_end}

{syntab :AUC plot}
{synopt :{it:{help cline_options}}}affect rendition of plotted points connected by lines{p_end}

{syntab :Add plot}
{synopt :{opth "addplot(addplot_option:plot)"}}add other plots to the generated graph{p_end}

{syntab :Y-Axis, X-Axis, Title, Caption, Legend, Overall}
{synopt :{it:{help twoway_options}}}any options other than {opt by()} documented in {bind:{bf:[G]} {it:twoway_options}}{p_end}
{synoptline}
{p2colreset}{...}
{p 4 6 2}
{opt by} may be used with {cmd:pkexamine}; see {helpb by}.


{title:Description}

{pstd}
{cmd:pkexamine} calculates pharmacokinetic measures from
time-and-concentration subject-level data.  {cmd:pkexamine} computes and
displays the maximum measured concentration, the time at the maximum
concentration, the time of the last measurement, the elimination time, the
half-life, and the area under the concentration-time curve (AUC).  Three
estimates of the area under the concentration-time curve from 0 to infinity
(AUC) are also calculated.

{pstd}
{cmd:pkexamine} is one of the pk commands.  Please read {helpb pk} before
reading this entry.


{title:Options}

{dlgtab:Main}

{phang}
{opt trapezoid} specifies that the trapezoidal rule, the sum of 
(xvar[i] - xvar[i-1])*(yvar[i] + yvar[i-1])/2, be used to calculate the
AUC.  The default is cubic splines, which give better results for most
functions.  In cases where the curve is very irregular, {opt trapezoid} may
give better results.

{phang}
{opt fit(#)} specifies the number of points, counting back from the last
measurement, to use in fitting the extension to estimate AUC from 0 to
infinity.  The default is {cmd:fit(3)}, or the last three points.  This should
be viewed as a minimum; the appropriate number of points will depend on your
data.

{phang}
{opt graph} tells {cmd:pkexamine} to graph the concentration-time curve.

{phang}
{opt line} and {opt log} specify the estimates of the AUC from 0 to infinity
to display when graphing the AUC from 0 to infinity.  These options are
ignored, unless they are specified with the {opt graph} option.

{phang}
{opt exp(#)} specifies that the exponential fit for the AUC from 0 to infinity
be plotted.  You must specify the maximum time value to which you want to plot
the curve, and this time value must be greater than the maximum time
measurement in the data.  If you specify 0, the curve will be plotted to the
point at which the linear extension would cross the x-axis.  This option is
not valid with the {opt line} or {opt log} options and is ignored, unless the
{opt graph} option is also specified.

{dlgtab:AUC plot}

{phang}
{it:cline_options} affect the rendition of the plotted points connected
by lines; see {it:{help cline_options}}.

{dlgtab:Add plot}

{phang}
{opt addplot(plot)} provides a way to add other plots to the generated
graph; see {it:{help addplot_option}}.

{dlgtab:Y-Axis, X-Axis, Title, Caption, Legend, Overall}

{phang}
{it:twoway_options} are any of the options documented in 
{it:{help twoway_options}}, excluding {opt by()}.  These include options for
titling the graph (see {it:{help title_options}}) and options for saving the
graph to disk (see {it:{help saving_option}}).


{title:Examples}

{p 4 40 2}{cmd:. pkexamine time conc} {space 12} (Show measures){p_end}

{p 4 40 2}{cmd:. pkexamine time conc, fit(7)} {space 4} (Use last 7 point to
	fit model){p_end}

{p 4 40 2}{cmd:. pkexamine time conc, trapezoid} {space 1} (Use trapezoidal
	rule in calculating AUC)


{title:Also see}

{psee}
Manual:  {bf:[R] pkexamine}

{psee}
Online:  {helpb pk}, {helpb pkcollapse}, {helpb pkcross},
{helpb pkequiv}, {helpb pkshape}, {helpb pksumm}, {helpb statsby}
{p_end}