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1: Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16558-63. Epub 2007 Oct 10.

Fibroblast growth factor receptor 2 regulates proliferation and Sertoli
differentiation during male sex determination.

Kim Y, Bingham N, Sekido R, Parker KL, Lovell-Badge R, Capel B.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710.

Targeted mutagenesis of Fgf9 in mice causes male-to-female sex reversal. Among
the four FGF receptors, FGFR2 showed two highly specific patterns based on
antibody staining, suggesting that it might be the receptor-mediating FGF9
signaling in the gonad. FGFR2 was detected at the plasma membrane in
proliferating coelomic epithelial cells and in the nucleus in Sertoli progenitor 
cells. This expression pattern suggested that Fgfr2 might play more than one role
in testis development. To test the hypothesis that Fgfr2 is required for male sex
determination, we crossed mice carrying a floxed allele of Fgfr2 with two
different Cre lines to induce a temporal or cell-specific deletion of this
receptor. Results show that deletion of Fgfr2 in embryonic gonads phenocopies
deletion of Fgf9 and leads to male-to-female sex reversal. Using these two Cre
lines, we provide the first genetic evidence that Fgfr2 plays distinct roles in
proliferation and Sertoli cell differentiation during testis development.

PMID: 17940049 [PubMed - in process]

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