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1: Expert Rev Mol Med. 2007 Jan 16;9(2):1-20.

Endometriosis: disease pathophysiology and the role of prostaglandins.

Wu MH, Shoji Y, Chuang PC, Tsai SJ.

Department of Obstetrics and Gynecology, National Cheng Kung University Medical
College, Tainan 701, Taiwan, Republic of China.

Endometriosis is considered to be a polygenic disease with a complex,
multifactorial aetiology that affects about 10% of women in the reproductive age.
Women with endometriosis have symptoms that include chronic pelvic pain,
dysmenorrhoea and dyspareunia, significantly reducing their quality of life.
Endometriosis is also the primary cause of infertility in women, with the
prevalence rate ranging from 20% to 50%. The high prevalence and severe outcomes 
of this disease have made it a major public health concern in modern society.
Currently, the mechanism(s) responsible for the initiation and promotion of this 
disease remains obscure. In this review, we focus on the expression, regulation
and action of prostaglandins in the cellular and molecular mechanisms that
contribute to the development and/or maintenance of endometriosis.

PMID: 17227592 [PubMed - indexed for MEDLINE]

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