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1: Dev Dyn. 2006 Sep;235(9):2292-300.

Balancing the bipotential gonad between alternative organ fates: a new
perspective on an old problem.

Kim Y, Capel B.

Department of Cell Biology, Duke University Medical Center, Durham, North
Carolina 27710, USA.

The embryonic gonads give rise to one of two morphologically and functionally
different organs, a testis or an ovary. Sex determination is the embryonic
process that determines the developmental fate of the gonad. In mammals, sex
determination is regulated by a DNA binding protein encoded on the Y chromosome, 
Sry, and it's downstream mediator, Sox9, which trigger testis determination in
the bipotential gonad. However, evidence suggests that the extracellular signals.
Fgf9 and Wnt4, are also required to establish divergent organogenesis of the
gonad. In this review, we discuss how these extracellular signals interface with 
cell-autonomous factors to determine the fate of the mammalian gonad, and we
derive a model that could provide a molecular explanation for testis
determination in vertebrates where Sry is absent. Copyright 2006 Wiley-Liss, Inc.

PMID: 16881057 [PubMed - indexed for MEDLINE]

Related Links

    Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex
determination. [PLoS Biol. 2006] PMID:16700629

    Determination and stability of sex. [Bioessays. 2007] PMID:17187356

    Sry and Sox9 expression during canine gonadal sex determination assayed by
quantitative reverse transcription-polymerase chain reaction. [Mol Reprod Dev.
2003] PMID:12840810

    The battle of the sexes. [Mech Dev. 2000] PMID:10704890

    Gonadal differentiation, sex determination and normal Sry expression in mice
require direct interaction between transcription partners GATA4 and FOG2.
[Development. 2002] PMID:12223418