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1: Development. 2006 Jan;133(1):173-80. Epub 2005 Nov 24.

Reciprocal epithelial-mesenchymal FGF signaling is required for cecal
development.

Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM.

Department of Molecular Biology and Pharmacology, Washington University School of
Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

Fibroblast growth factor (FGF) signaling mediates reciprocal
mesenchymal-epithelial cell interactions in the developing mouse lung and limb.
In the gastrointestinal (GI) tract, FGF10 is expressed in the cecal mesenchyme
and signals to an epithelial splice form of FGF receptor (FGFR) 2 to regulate
epithelial budding. Here, we identify FGF9 as a reciprocal epithelial-mesenchymal
signal required for cecal morphogenesis. Fgf9 null (Fgf9(-/-)) mouse embryos have
agenesis of the embryonic cecum, lacking both mesenchymal expansion and an
epithelial bud. In the cecal region of Fgf9(-/-) embryos, mesenchymal expression 
of Fgf10 and Bmp4 is notably absent, whereas the expression of epithelial
markers, such as sonic hedgehog, is not affected. Using epithelial and whole
explant cultures, we show that FGF9 signals to mesenchymal FGFRs and that FGF10
signals to epithelial FGFRs. Taken together, these data show that an epithelial
FGF9 signal is necessary for the expansion of cecal mesenchyme and the expression
of mesenchymal genes that are required for epithelial budding. Thus, these data
add to our understanding of FGF-mediated reciprocal epithelial-mesenchymal
signaling.

PMID: 16308329 [PubMed - indexed for MEDLINE]

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