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1: Brain Res. 2006 Feb 16;1073-1074:88-92. Epub 2006 Feb 3.

Differential gene expression in central nervous system tissues of sheep with
natural scrapie.

Garcia-Crespo D, Juste RA, Hurtado A.

Department of Animal Health, Instituto Vasco de Investigación y Desarrollo
Agrario (NEIKER); Berreaga, 1. 48160 Derio, Bizkaia, Spain.

The expression of nine genes was analyzed by real-time RT-PCR in the central
nervous system in order to investigate the molecular pathogenesis of natural
scrapie. An up-regulation of genes related to glial activation (GFAP) and
apoptosis (CASP3) was detected in obex and cerebrum, indicating a reactive glia. 
Another glial activation-related gene (CTSS) was slightly up-regulated in obex,
whereas constitutive expression was detected for SOD1, YWHAZ, PRNP, and the
apoptosis-related genes BCL2, MCL1, and BAX. This differential gene expression
might reflect a spatial-temporal and tissue-specific molecular pathogenesis of
scrapie.

PMID: 16458864 [PubMed - indexed for MEDLINE]

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