48.txt

the test core for find word in xxx.txt

1: J Dermatol. 2006 May;33(5):309-18.

Genome-wide transcriptional profiling in human squamous cell carcinoma of the
skin identifies unique tumor-associated signatures.

Kathpalia VP, Mussak EN, Chow SS, Lam PH, Skelley N, Time M, Markelewicz RJ Jr,
Kanduc D, Lomas L, Xiang Z, Sinha AA.

Department of Dermatology, Weill Cornell Medical College, New York, New York,
USA.

The elucidation of specific genetic changes associated with human cancer
pathogenesis has focused efforts to relate such changes to the neoplastic
phenotype. To further our understanding of the genetic basis of human squamous
cell carcinoma (SCC) of the skin, this study used a genome-wide (12 627
sequences) approach to determine transcriptional signatures in lesional and
nonlesional sites from five SCC patients. Several novel genes involving the p53
pathway, anti-apoptotic pathways, signal transduction, structural loss and DNA
replication, including BCL2A1, MUC4, PTPN11 (SHP2) and FGF9, are upregulated in
SCC and could warrant further study regarding their role in disease pathogenesis.
SCC pathology is likely combinatorial in nature involving the compounded changes 
from several cellular processes.

PMID: 16700662 [PubMed - indexed for MEDLINE]

Related Links

    Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines
identified by DNA microarrays and qRT-PCR. [Biochem Biophys Res Commun. 2003]
PMID:12821146

    Gene expression profiling of head and neck squamous cell carcinoma using cDNA
microarrays. [Int J Oncol. 2006] PMID:16865276

    Transcriptional gene expression profile of human esophageal squamous cell
carcinoma. [Genomics. 2003] PMID:12706106

    Gene expression profiling in squamous cell carcinoma of the oral cavity shows
abnormalities in several signaling pathways. [Laryngoscope. 2005] PMID:15805883

    Genome-wide comparison of human keratinocyte and squamous cell carcinoma
responses to UVB irradiation: implications for skin and epithelial cancer.
[Oncogene. 2003] PMID:12771951