19.txt

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1: Angle Orthod. 2006 Nov;76(6):990-5.

Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing
mouse cranial base.

Nie X.

Department of Biomedicine, University of Bergen, Bergen, Norway.
[e-mail]

OBJECTIVE: To examine the expression pattern of the Fgf and Msx genes in cranial 
base development. MATERIALS AND METHODS: To detect the expression of these genes,
antisense riboprobes were synthesized by in vitro transcription. Radioactive in
situ hybridization was performed on parasagittal sections of embryonic mouse
heads. RESULTS: Msx2 was observed in the underlying perichondrium at restricted
stages. Msx1 was not observed in cranial base development. Fgf1 was localized in 
osteogenic cells from the time of ossification; Fgf10 was highly expressed in the
occipital-vertebral joint during E13 to E14; Fgf2, Fgf7, and Fgf18 were localized
in the perichondria; Fgf12 was transitorily expressed at early chondrocranium;
Fgf9 was seen in the hypertrophic chondrocytes. CONCLUSIONS: The Fgf and Msx gene
expression in the cranial base was different from that of other skeletons.

PMID: 17090159 [PubMed - indexed for MEDLINE]

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