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1: Endocrinology. 2006 Aug;147(8):3777-88. Epub 2006 May 4.

Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth
factor 9-induced mesonephric cell migration to the developing testis.

Chi L, Itäranta P, Zhang S, Vainio S.

Department of Biochemistry, University of Oulu, Finland.

Fibroblast growth factor 9 (FGF9) signal has a role in organogenesis of the
mammalian testis by controlling migration of mesonephric cells to the XY gonad,
but neither it nor the FGF receptors is expressed sex-specifically. Of the
Sprouty genes encoding antagonists of receptor tyrosine kinases including FGFr,
mSprouty2 expression was confined to the developing testis and mesonephros. Gain 
of SPROUTY2 function in the male genital ridge and mesonephros malformed the vas 
deferens and epididymis, and diminished the number of seminiferous tubules and
interstitium associating with reduced mesonephric cell migration and Fgf9
expression in embryonic testis, whereas exogenous FGF9 signaling recovered
mesonephric cell migration inhibited by SPROUTY2. These phenotypes associated
also with the decreased expression of Sox9, Desert hedgehog, Hsd3beta,
Platelet/endothelial cell adhesion molecule, and alpha-smooth muscle actin, which
are markers of the Sertoli, Leydig, endothelial, and peritubular myoid cells of
the developing testis. Based on these data, we propose that the Sprouty proteins 
are involved normally in mediating the sexually dimorphic signaling of FGF9 and
controlling cell migration from the mesonephros during testis development.

PMID: 16675530 [PubMed - indexed for MEDLINE]

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