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1: Inflamm Bowel Dis. 2006 Jun;12(6):471-7.

Profiling adipocytokine secretion from creeping fat in Crohn's disease.

Paul G, Schäffler A, Neumeier M, Fürst A, Bataillle F, Buechler C, Müller-Ladner 
U, Schölmerich J, Rogler G, Herfarth H.

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

BACKGROUND: Adipose tissue is recognized as a compartment secreting highly active
molecules. Creeping fat represents a characteristic feature of Crohn's disease
(CD). Proinflammatory or anti-inflammatory adipose-derived secretory products,
now generally called adipocytokines, may play a role in the pathogenesis of CD.
MATERIALS AND METHODS: Adipose tissue specimens were obtained from creeping fat
contiguous to the involved intestine of 10 patients with CD. Mesenteric adipose
tissue specimens resected from 13 patients with colon cancer (CC) and from 7
patients with diverticulitis served as controls. Three fat tissue specimen per
well and 6 to 8 wells per patient were incubated ex vivo for 24 h. The release of
adiponectin, resistin, leptin, interleukin-6, macrophage colony-stimulating
factor, monocyte chemotactic protein-1, and migration inhibitory factor was
measured by ELISA. The expression of AdipoR1 and AdipoR2 receptors was
investigated by real-time quantitative polymerase chain reaction in a subset of
adipose tissues. RESULTS: The secretion of adiponectin and macrophage
colony-stimulating factor, as well as leptin and migration inhibitory factor, was
significantly upregulated in CD compared with CC and diverticulitis or CC only,
respectively. Resistin, interleukin-6, and monocyte chemotactic protein-1 were
not specifically induced in CD but were associated with unspecific inflammation. 
Adiponectin receptor expression was not different in CC, CD, or diverticulitis.
Steroid treatment in CD patients had differential effects on the ex vivo
secretion of adipocytokines. CONCLUSIONS: A specific secretion pattern of
proinflammatory and anti-inflammatory adipocytokines indicates the significance
of adipose tissue in intestinal inflammation in CD. Future investigations of this
intestinal compartment may provide novel insights into the pathophysiological
role of creeping fat and CD.

PMID: 16775490 [PubMed - indexed for MEDLINE]

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