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Data Arangement:                  Y          ------------------      (X)  A    C    G    U          ------------------              5' ==> 3'                 AX                 AY              3' <== 5'      (A)   .     .     .     .      (C)   .     .     .     .      (G)   .     .     .     .      (U) -0.70 -0.10 -0.70 -0.10 -------------------------------- STACKING ENTHALPIES : TERMINAL MISMATCHES           Y                       Y                       Y                       Y   ------------------      ------------------      ------------------      ------------------    A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   ------------------      ------------------      ------------------      ------------------       5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'          AX                      AX                      AX                      AX          AY                      CY                      GY                      UY       3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   .     .     .   -4.00   .     .     .   -4.30   .     .     .   -3.80 -4.30 -6.00 -6.00 -6.00   .     .   -5.20   .     .     .   -7.20   .     .     .   -7.10   .   -2.60 -2.40 -2.40 -2.40   .   -10.30  .   -7.20   .   -5.20   .   -4.80   .   -9.40   .   -6.60 -3.40 -6.90 -6.90 -6.90 -4.30   .   -4.30   .   -2.60   .   -2.60   .   -3.40   .   -3.40   .   -3.30 -3.30 -3.30 -3.30           Y                       Y                       Y                       Y   ------------------      ------------------      ------------------      ------------------    A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   ------------------      ------------------      ------------------      ------------------       5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'          CX                      CX                      CX                      CX          AY                      CY                      GY                      UY       3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   .     .     .   -6.30   .     .     .   -5.10 -10.30-9.50 -10.30-10.30  .     .     .   -1.40   .     .   -8.80   .     .     .   -3.10   .   -5.20 -4.50 -5.20 -6.70   .     .   -5.00   .   .   -9.50   .   -7.90   .   -4.50   .   -4.80 -9.40 -9.40 -9.40 -9.40   .   -7.40   .   -4.40 -6.00   .   -6.00   .   -2.40   .   -2.40   .   -8.10 -7.40 -8.10 -8.60 -3.30   .   -3.30   .           Y                       Y                       Y                       Y   ------------------      ------------------      ------------------      ------------------    A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   ------------------      ------------------      ------------------      ------------------       5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'          GX                      GX                      GX                      GX          AY                      CY                      GY                      UY       3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   .     .     .   -8.90 -5.20 -8.80 -5.60 -8.80   .     .     .   -8.90 -4.30 -6.00 -6.00 -6.00   .     .   -5.60   .   -7.20 -3.10 -3.10 -3.90   .     .   -6.20   .   -2.60 -2.40 -2.40 -2.40   .   -10.30  .   -9.60 -7.10 -7.40 -6.20 -7.40   .   -9.40   .   -9.20 -3.40 -6.90 -6.90 -6.90 -6.00   .   -6.00   .   -5.00 -5.00 -5.00 -5.70 -6.90   .   -6.90   .   -3.30 -3.30 -3.30 -3.30           Y                       Y                       Y                       Y   ------------------      ------------------      ------------------      ------------------    A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   ------------------      ------------------      ------------------      ------------------       5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'          UX                      UX                      UX                      UX          AY                      CY                      GY                      UY       3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5' -4.00 -6.30 -8.90 -5.90   .     .     .   -1.80 -7.20 -7.90 -9.60 -8.10   .     .     .    1.40 -4.30 -5.10 -2.00 -1.80   .     .   -3.90   .   -4.80 -4.80 -3.60 -4.80   .     .   -5.70   . -3.80 -6.80 -8.90 -6.80   .   -6.70   .   -4.80 -6.60 -8.10 -9.20 -8.10   .   -8.60   .   -3.60 -2.80 -1.40 -2.80 -1.40 -2.40   .   -2.40   .   -5.50 -4.40 -5.50 -3.60 -3.30   .   -3.30   . 

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