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-1.32 -1.42 -1.32 -1.84 -1.87 -1.97 -1.87 -2.39 -1.90 -2.00 -1.90 -2.42 -1.32 -1.42 -1.32 -1.84 -0.77 -0.87 -0.77 -1.29 -0.77 -0.87 -0.77 -1.29 -1.48 -1.48 0.00 -1.48 -2.03 -2.03 -0.55 -2.03 -2.06 -2.06 -0.58 -2.06 -1.48 -1.48 0.00 -1.48 -0.87 -0.87 0.61 -0.87 -0.87 -0.87 0.61 -0.87 -3.32 -4.26 -3.32 -1.61 -3.58 -4.51 -3.58 -1.87 -3.16 -4.09 -3.16 -1.45 -3.42 -4.35 -3.42 -1.71 0.32 -0.61 0.32 2.03 0.71 -0.23 0.71 2.42 -2.32 -1.45 -0.19 -1.45 -2.87 -2.00 -0.74 -2.00 -2.87 -2.00 -0.74 -2.00 -2.32 -1.45 -0.19 -1.45 -1.74 -0.87 0.39 -0.87 -1.74 -0.87 0.39 -0.87 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G T A C G T A C G T A C G T A C G T A C G T ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G T G G G T T T T G T C T A T T T G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -1.29 -1.39 -1.29 -1.81 -1.81 -1.90 -1.81 -2.32 -1.84 -1.93 -1.84 -2.35 -1.29 -1.39 -1.29 -1.81 -0.68 -0.77 -0.68 -1.19 -0.68 -0.77 -0.68 -1.19 -3.68 -3.68 -2.19 -3.68 -3.26 -3.26 -1.77 -3.26 -4.00 -4.00 -2.51 -4.00 -3.39 -3.39 -1.90 -3.39 -2.10 -2.10 -0.61 -2.10 -1.71 -1.71 -0.23 -1.71 -1.29 -2.22 -1.29 0.42 -1.81 -2.74 -1.81 -0.10 -1.84 -2.77 -1.84 -0.13 -1.29 -2.22 -1.29 0.42 -0.68 -1.61 -0.68 1.03 -0.68 -1.61 -0.68 1.03 -1.84 -0.97 0.29 -0.97 -0.64 0.23 1.48 0.23 -2.97 -2.10 -0.84 -2.10 -1.48 -0.61 0.64 -0.61 -2.26 -1.39 -0.13 -1.39 0.06 0.94 2.19 0.94 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G T A C G T A C G T A C G T A C G T A C G T ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G T G G G T T T T G T C T A T T T G YT YT YT YT YT YT 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -3.39 -3.48 -3.39 -3.90 -3.42 -3.51 -3.42 -3.93 -3.29 -3.39 -3.29 -3.80 -3.16 -3.26 -3.16 -3.68 -0.52 -0.61 -0.52 -1.03 -1.64 -1.74 -1.64 -2.16 -1.45 -1.45 0.03 -1.45 -2.00 -2.00 -0.52 -2.00 -2.00 -2.00 -0.52 -2.00 -1.45 -1.45 0.03 -1.45 -0.87 -0.87 0.61 -0.87 -0.87 -0.87 0.61 -0.87 -1.23 -2.16 -1.23 0.48 -2.13 -3.06 -2.13 -0.42 -1.61 -2.55 -1.61 0.10 -1.64 -2.58 -1.64 0.06 1.03 0.10 1.03 2.74 0.48 -0.45 0.48 2.19 -2.26 -1.39 -0.13 -1.39 -2.81 -1.93 -0.68 -1.93 -2.81 -1.93 -0.68 -1.93 -2.26 -1.39 -0.13 -1.39 -1.74 -0.87 0.39 -0.87 -1.74 -0.87 0.39 -0.87 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G T A C G T A C G T A C G T A C G T A C G T ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X T A T C T G T T T G T T G T G G G C G A G T G G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -1.29 -1.39 -1.29 -1.48 -1.77 -1.87 -1.77 -1.97 -1.81 -1.90 -1.81 -2.00 -1.26 -1.35 -1.26 -1.45 -0.68 -0.77 -0.68 -0.87 -0.68 -0.77 -0.68 -0.87 -1.42 -1.42 -0.32 -1.42 -1.97 -1.97 -0.87 -1.97 -2.00 -2.00 -0.90 -2.00 -1.42 -1.42 -0.32 -1.42 -0.87 -0.87 0.23 -0.87 -0.87 -0.87 0.23 -0.87 -1.29 -2.61 -1.29 -1.90 -1.81 -3.13 -1.81 -2.42 -1.84 -3.16 -1.84 -2.45 -1.29 -2.61 -1.29 -1.90 -0.68 -2.00 -0.68 -1.29 -0.68 -2.00 -0.68 -1.29 -3.00 -3.26 -1.45 -3.26 -3.16 -3.42 -1.61 -3.42 -3.29 -3.55 -1.74 -3.55 -3.22 -3.48 -1.68 -3.48 -0.71 -0.97 0.84 -0.97 -1.03 -1.29 0.52 -1.29 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G T A C G T A C G T A C G T A C G T A C G T ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X T A T C T G T T T G T T G T G G G C G A G T G G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -1.32 -1.42 -1.32 -1.52 -1.87 -1.97 -1.87 -2.06 -1.90 -2.00 -1.90 -2.10 -1.32 -1.42 -1.32 -1.52 -0.77 -0.87 -0.77 -0.97 -0.77 -0.87 -0.77 -0.97 -1.48 -1.48 -0.39 -1.48 -2.03 -2.03 -0.94 -2.03 -2.06 -2.06 -0.97 -2.06 -1.48 -1.48 -0.39 -1.48 -0.87 -0.87 0.23 -0.87 -0.87 -0.87 0.23 -0.87 -3.32 -4.64 -3.32 -3.93 -3.58 -4.90 -3.58 -4.19 -3.16 -4.48 -3.16 -3.77 -3.42 -4.74 -3.42 -4.03 0.32 -1.00 0.32 -0.29 0.71 -0.61 0.71 0.10 -1.19 -1.45 0.35 -1.45 -1.74 -2.00 -0.19 -2.00 -1.74 -2.00 -0.19 -2.00 -1.19 -1.45 0.35 -1.45 -0.61 -0.87 0.94 -0.87 -0.61 -0.87 0.94 -0.87 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G T A C G T A C G T A C G T A C G T A C G T ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X T A T C T G T T T G T T G T G G G C G A G T G G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -1.29 -1.39 -1.29 -1.48 -1.81 -1.90 -1.81 -2.00 -1.84 -1.93 -1.84 -2.03 -1.29 -1.39 -1.29 -1.48 -0.68 -0.77 -0.68 -0.87 -0.68 -0.77 -0.68 -0.87 -3.68 -3.68 -2.58 -3.68 -3.26 -3.26 -2.16 -3.26 -4.00 -4.00 -2.90 -4.00 -3.39 -3.39 -2.29 -3.39 -2.10 -2.10 -1.00 -2.10 -1.71 -1.71 -0.61 -1.71 -1.29 -2.61 -1.29 -1.90 -1.81 -3.13 -1.81 -2.42 -1.84 -3.16 -1.84 -2.45 -1.29 -2.61 -1.29 -1.90 -0.68 -2.00 -0.68 -1.29 -0.68 -2.00 -0.68 -1.29 -0.71 -0.97 0.84 -0.97 0.48 0.23 2.03 0.23 -1.84 -2.10 -0.29 -2.10 -0.35 -0.61 1.19 -0.61 -1.13 -1.39 0.42 -1.39 1.19 0.94 2.74 0.94 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G T A C G T A C G T A C G T A C G T A C G T ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X T A T C T G T T T G T T G T G G G C G A G T G G YT YT YT YT YT YT 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -3.39 -3.48 -3.39 -3.58 -3.42 -3.51 -3.42 -3.61 -3.29 -3.39 -3.29 -3.48 -3.16 -3.26 -3.16 -3.35 -0.52 -0.61 -0.52 -0.71 -1.64 -1.74 -1.64 -1.84 -1.45 -1.45 -0.35 -1.45 -2.00 -2.00 -0.90 -2.00 -2.00 -2.00 -0.90 -2.00 -1.45 -1.45 -0.35 -1.45 -0.87 -0.87 0.23 -0.87 -0.87 -0.87 0.23 -0.87 -1.23 -2.55 -1.23 -1.84 -2.13 -3.45 -2.13 -2.74 -1.61 -2.93 -1.61 -2.22 -1.64 -2.97 -1.64 -2.26 1.03 -0.29 1.03 0.42 0.48 -0.84 0.48 -0.13 -1.13 -1.39 0.42 -1.39 -1.68 -1.93 -0.13 -1.93 -1.68 -1.93 -0.13 -1.93 -1.13 -1.39 0.42 -1.39 -0.61 -0.87 0.94 -0.87 -0.61 -0.87 0.94 -0.87
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