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    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            C  A                    C  C                    C  G                    C  U                    C  G                    C  U            G  U                    G  G                    G  C                    G  A                    G  U                    G  G             YC                      YC                      YC                      YC                      YC                      YC         3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   2.90  2.90  1.70  2.50  2.40  2.40  1.20  2.00  2.40  2.40  1.20  2.00  2.90  2.90  1.70  2.50  2.90  2.90  1.70  2.50  2.40  2.40  1.20  2.00   2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40  2.40  2.40  2.90  2.40  2.90  2.90  3.40  2.90  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40   2.90  3.70  4.10  3.70  2.10  2.90  3.30  2.90  1.70  2.50  2.90  2.50  2.50  3.30  3.70  3.30  2.90  3.70  4.10  3.70  2.10  2.90  3.30  2.90   3.00  2.90  3.00  1.90  2.50  2.40  2.50  1.40  2.50  2.40  2.50  1.40  3.00  2.90  3.00  1.90  3.00  2.90  3.00  1.90  2.50  2.40  2.50  1.40             Y                       Y                       Y                       Y                       Y                       Y     ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            C  A                    C  C                    C  G                    C  U                    C  G                    C  U            G  U                    G  G                    G  C                    G  A                    G  U                    G  G             YG                      YG                      YG                      YG                      YG                      YG         3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   1.70  1.70  0.50  1.30  1.20  1.20  0.00  0.80  1.20  1.20  0.00  0.80  1.70  1.70  0.50  1.30  1.70  1.70  0.50  1.30  1.20  1.20  0.00  0.80   3.50  3.50  4.00  3.50  2.40  2.40  2.90  2.40  2.00  2.00  2.50  2.00  3.40  3.40  3.90  3.40  3.50  3.50  4.00  3.50  2.40  2.40  2.90  2.40   1.70  2.50  2.90  2.50  1.20  2.00  2.40  2.00  1.20  2.00  2.40  2.00  1.70  2.50  2.90  2.50  1.70  2.50  2.90  2.50  1.20  2.00  2.40  2.00   3.60  3.50  3.60  2.50  2.50  2.40  2.50  1.40  2.10  2.00  2.10  1.00  3.50  3.40  3.50  2.40  3.60  3.50  3.60  2.50  2.50  2.40  2.50  1.40             Y                       Y                       Y                       Y                       Y                       Y     ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            C  A                    C  C                    C  G                    C  U                    C  G                    C  U            G  U                    G  G                    G  C                    G  A                    G  U                    G  G             YU                      YU                      YU                      YU                      YU                      YU         3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   4.10  4.10  2.90  3.70  3.10  3.10  1.90  2.70  2.50  2.50  1.30  2.10  3.60  3.60  2.40  3.20  4.10  4.10  2.90  3.70  3.10  3.10  1.90  2.70   2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40  2.40  2.40  2.90  2.40  2.90  2.90  3.40  2.90  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40   2.90  3.70  4.10  3.70  1.90  2.70  3.10  2.70  1.30  2.10  2.50  2.10  2.40  3.20  3.60  3.20  2.90  3.70  4.10  3.70  1.90  2.70  3.10  2.70   2.00  1.90  2.00  0.90  1.50  1.40  1.50  0.40  1.50  1.40  1.50  0.40  2.00  1.90  2.00  0.90  2.00  1.90  2.00  0.90  1.50  1.40  1.50  0.40             Y                       Y                       Y                       Y                       Y                       Y     ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            G  A                    G  C                    G  G                    G  U                    G  G                    G  U            C  U                    C  G                    C  C                    C  A                    C  U                    C  G             YA                      YA                      YA                      YA                      YA                      YA         3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60  2.40  2.40  1.20  2.60  2.90  2.90  1.70  3.10  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60   2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40   0.50  1.70  1.70  1.70  0.00  1.20  1.20  1.20  0.00  1.20  1.20  1.20  0.50  1.70  1.70  1.70  0.50  1.70  1.70  1.70  0.00  1.20  1.20  1.20   4.20  3.50  4.20  2.50  3.30  2.60  3.30  1.60  2.70  2.00  2.70  1.00  4.10  3.40  4.10  2.40  4.20  3.50  4.20  2.50  3.30  2.60  3.30  1.60             Y                       Y                       Y                       Y                       Y                       Y     ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            G  A                    G  C                    G  G                    G  U                    G  G                    G  U            C  U                    C  G                    C  C                    C  A                    C  U                    C  G             YC                      YC                      YC                      YC                      YC                      YC         3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60  2.40  2.40  1.20  2.60  2.90  2.90  1.70  3.10  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60   2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40   2.90  4.10  4.10  4.10  2.10  3.30  3.30  3.30  1.70  2.90  2.90  2.90  2.50  3.70  3.70  3.70  2.90  4.10  4.10  4.10  2.10  3.30  3.30  3.30   3.60  2.90  3.60  1.90  3.10  2.40  3.10  1.40  3.10  2.40  3.10  1.40  3.60  2.90  3.60  1.90  3.60  2.90  3.60  1.90  3.10  2.40  3.10  1.40             Y                       Y                       Y                       Y                       Y                       Y     ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            G  A                    G  C                    G  G                    G  U                    G  G                    G  U            C  U                    C  G                    C  C                    C  A                    C  U                    C  G             YG                      YG                      YG                      YG                      YG                      YG         3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'   1.70  1.70  0.50  1.90  1.20  1.20  0.00  1.40  1.20  1.20  0.00  1.40  1.70  1.70  0.50  1.90  1.70  1.70  0.50  1.90  1.20  1.20  0.00  1.40   3.50  3.50  4.40  3.50  2.40  2.40  3.30  2.40  2.00  2.00  2.90  2.00  3.40  3.40  4.30  3.40  3.50  3.50  4.40  3.50  2.40  2.40  3.30  2.40   1.70  2.90  2.90  2.90  1.20  2.40  2.40  2.40  1.20  2.40  2.40  2.40  1.70  2.90  2.90  2.90  1.70  2.90  2.90  2.90  1.20  2.40  2.40  2.40   4.20  3.50  4.20  2.50  3.10  2.40  3.10  1.40  2.70  2.00  2.70  1.00  4.10  3.40  4.10  2.40  4.20  3.50  4.20  2.50  3.10  2.40  3.10  1.40             Y                       Y                       Y                       Y                       Y                       Y     ------------------      ------------------      ------------------      ------------------      ------------------      ------------------      A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U       ------------------      ------------------      ------------------      ------------------      ------------------      ------------------         5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'             X                       X                       X                       X                       X                       X            G  A                    G  C                    G  G                    G  U                    G  G                    G  U 

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