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85239517 treatment childhood raynaud disease transdermal prostaglandin analogue86045706 method correction hemorheological disorders patients with thrombobliterating diseases the peripheral arteries the limbs methods plasm and plasmoerythrocytapheresis combination with hemodilution were used patients with thrombobliterating diseases the extremity arteries conclusion made the necessary detection hemorheological disturbances this group patients the methods used were shown promising the correlation was established between changes the rheological properties blood and clinical course the disease85278371 lung involvement sjogren syndrome comparison between patients with primary and with secondary syndrome lung function was assessed patients with primary sjogren syndrome and group patients with associated with variety connective tissue diseases signs small airway disease and altered diffusion capacity together with chest ray features mild interstitial involvement were the most common findings primary the whole lung involvement was more frequent and severe patients with the secondary form the syndrome both primary and secondary lung function changes did not correlate with the other clinical and serological parameters except for more severe impairment diffusion capacity patients with raynaud phenomenon85277349 pathogenesis raynaud phenomenon disease and syndrome85251849 pulmonary involvement systemic sclerosis scleroderma one hundred sixty five nonsmoking systemic sclerosis patients were evaluated pulmonary function testing restrictive lung disease and isolated reduction the diffusing capacity carbon monoxide were the most frequent abnormalities patients with the crest syndrome calcinosis raynaud phenomenon esophageal dysmotility sclerodactyly and telangiectasias had similar frequency and severity pulmonary involvement compared with the patients who had diffuse scleroderma crest syndrome patients with restrictive lung disease rarely had the anticentromere antibody and had more skin and joint involvement their hands compared with other crest syndrome patients dyspnea and rales were most commonly found patients with restrictive lung disease fibrosis shown chest radiograph and pulmonary function abnormalities correlated poorly with each other dyspnea was associated with restrictive disease and rales were more commonly found patients with fibrosis patients with restrictive abnormality had the worst prognosis with year survival rate although death from pulmonary causes was uncommon comparison these nonsmoking patients with scleroderma patients who smoked seen during the same time period revealed more frequent and severe obstructive changes smokers smoking patients with restrictive lung disease had more severe disease than nonsmoking patients the single breath diffusing capacity for carbon monoxide was significantly decreased the patients who smoked compared with the nonsmokers these data confirm that pulmonary function abnormalities are common patients with systemic sclerosis including crest syndrome smoking appears have additive deleterious effect pulmonary function and should strongly discouraged85249086 lumbar sympathectomy for lower extremity vasospasm ten patients female and male with refractory episodic lower extremity vasospasm were encountered during year period which over patients with upper extremity vasospasm were studied seven patients had associated upper extremity vasospasm patient had evidence autoimmune disease lower extremity reserpine bier block produced symptomatic relief for days all patients whom was used oral medications were ineffectual diagnostic toe photoplethysmographic pattern was noted these patients consisting normally pulsatile tracing after warming and flat nonpulsatile minimally pulsatile tracing after cooling each patient underwent lumbar sympathectomy during follow which averaged years each patient remained free episodic vasospasm the side surgery conclude that lumbar sympathectomy effective and durable treatment for lower extremity vasospasm86043776 prostacyclin therapy peripheral artery disease86028782 subclinical manifestations autoimmune rheumatic diseases primary raynaud phenomenon twenty nine patients with primary raynaud phenomenon underwent functional pulmonary functional studies and oesophageal manometry histologic minor salivary gland biopsy and serologic autoantibodies evaluation for subclinical manifestations autoimmune rheumatic disease ard seven has strong evidence and eight possible evidence ard all patients with strong evidence ard had raynaud phenomenon with duration less than five years this study suggests that such manifestations are frequent patients wih primary raynaud phenomenon and can detected with non aggressive methods which should used early the course their disease85251850 angiographic findings mixed connective tissue disease correlation with fingernail capillary photomicroscopy and digital photoplethysmography findings thirteen patients with mixed connective tissue disease underwent hand angiography assess the degree vascular abnormalities and their correlation nailfold capillary microscopy and digital photoplethysmography findings organic obstruction was found ulnar arteries superficial arches deep arches and digital arteries fingernail capillary abnormalities were seen patients normal photoplethysmography results had predictive value for identifying digits without bilateral occlusions these findings indicate hitherto unrecognized propensity for disease both small and medium sized vessels patients with mixed connective tissue disease85278370 antikeratin antibodies serum and synovial fluid show specificity for rheumatoid arthritis study connective tissue diseases tests for antikeratin antibodies aka were performed disease associated and control sera indirect immunofluorescence rat oesophagus substrate the incidence aka was significantly raised rheumatoid arthritis comparison with systemic sclerosis psoriasis ankylosing spondylitis systemic lupus erythematosus and normal controls aka were detected synovial fluid obtained from patients with rheumatoid arthritis but not from patients with other conditions further experiments aka positive sera showed reactivity with stratum corneum rabbit prepuce and lips specific rabbit antihuman keratin antiserum was shown and inhibition studies have different specificity from that spontaneous human aka aka were associated with the presence subcutaneous nodules but not with raynaud phenomenon sjogren syndrome hla dr4 positivity rheumatoid factor was not associated with aka either positive disease controls85270276 quantitative test for measuring vascular reactivity cold the digital plethysmography technic86011209 assessment esophageal abnormalities progressive systemic sclerosis using radionuclide transit radionuclide transit noninvasive test esophageal function with sensitivity equivalent manometry using patients with progressive systemic sclerosis pss with diffuse scleroderma and with the crst variant were studied and compared patients with other connective tissue diseases and normal volunteers abnormalities were present patients with diffuse scleroderma with crst with other connective tissue diseases and none the controls the most frequent abnormality pss was that adynamic transit abnormalities correlated with disease duration the diffuse scleroderma group but not the crst group there was positive association between abnormal and the presence esophagitis the pss patients85299650 capillary microscopy the nail fold raynaud phenomenon use the early diagnosis scleroderma85264431 naloxone increases blood flow the human hand intravenous injection naloxone produced rapid and pronounced rise blood flow min and skin temperature degrees the finger and hand seven ten normal volunteers the other three there was only small response skin temperature did not change either the face the foot three responding subjects who were retested with naloxone showed smaller and briefer response exclude local effect naloxone skin blood flow due release histamine responders and non responders were tested with naloxone and morphine pricked into the skin the hand and forearm all showed weal and flare reaction morphine which was not abolished mixture with naloxone none showed any reaction naloxone alone these results suggest that some subjects least skin blood flow the hand may under endogenous opioid control and they raise the possibility that opioid antagonists might have value the treatment disorders skin blood flow such raynaud disease85251447 comparison the hunting reaction normals and individuals with raynaud disease cold induced vasodilation civd hunting reaction was studied eight subjects with raynaud disease idiopathic vasospastic disorder the peripheral vasculature and nine normal subjects using degree water bath immersions the right middle finger differences between raynaud and normal subjects were only marginal degrees degrees raynaud subjects showed longer time the first rise skin temperature had lower mean digital skin temperature and lower amplitude their digital skin temperature during civd degrees raynaud subjects had longer time first rise lower number civd cycles and lower recovery temperature85225790 comparison the specificity the and american rheumatism association criteria for the classification systemic lupus erythematosus the specificity the preliminary and the revised american rheumatism association criteria for the classification systemic lupus erythematosus sle was tested our patients with other rheumatic diseases which were considered important the differential diagnosis sle using the preliminary criteria the data revealed that patients were falsely classified having sle with scleroderma with raynaud disease and with systemic necrotizing vasculitis whereas using the revised criteria only patients with scleroderma and with systemic necrotizing vasculitis were falsely classified the calculated specificity was for the revised criteria and for the preliminary criteria thus the data revealed that the specificity the revised criteria high and comparable with that the preliminary criteria when applied group patients with related rheumatic diseases85270730 increased prostacyclin metabolites and decreased red cell deformability patients with systemic sclerosis and raynaud syndrome85225800 application japanese patients the american rheumatism association revised criteria for the classification systemic lupus erythematosus the american rheumatism association revised criteria for the classification systemic lupus erythematosus were tested

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