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85255421 effects beta adrenoreceptor blocking drugs patients with raynaud phenomenon digital vasospastic phenomena have been reported result from use nonselective and cardioselective beta adrenoreceptor blocking drugs the effects day propranolol and day metoprolol finger hemodynamics and clinical responses were compared with those placebo patients with raynaud phenomenon double blind week crossover study design was used with week washout placebo period between drugs total fingertip blood flow fbf determined venous occlusion plethysmography fingertip capillary flow fcf determined radioisotope disappearance rate and finger systolic blood pressure fsp were measured degrees and degrees room the end each period subjects kept diaries record vasospastic attacks there were significant changes fbf fcf fsp the warm cool environment during drug treatment compared with during the placebo period decrease pulse rate occurred with both drugs and there was decrease blood pressure with metoprolol there were significant changes the number vasospastic attacks the patients overall evaluation their conditions while they were receiving the drugs concluded that the presence raynaud phenomenon not contraindication the use beta adrenoreceptor blocking drugs the normotensive population
86042842 the effect prostacyclin analogue iloprost skin temperature skin temperature was measured the forearms healthy volunteers study the effect transdermal application stable prostacyclin analogue iloprost local skin temperature was significantly increased hours and hours after application the drug when compared with area control skin the effect had worn off hours dose micrograms there were systemic effects vasodilatation antiplatelet behaviour but when the dose was increased micrograms there was decreased rate platelet aggregation for hours histology skin biopsy suggested that the increase skin temperature was due vasodilatation and not acute inflammatory reaction the results this pilot study suggest that transdermal application iloprost suitable vehicle for administration the drug and prospective randomised trial proposed for patients with raynaud syndrome
86034818 persisting raynaud phenomenon following intralesional bleomycin treatment finger warts
86097648 evening primrose oil efamol the treatment raynaud phenomenon double blind study prostaglandin pge1 and prostacyclin have been used raynaud phenomenon but are unstable and require intravenous administration alternative approach stimulate the body own pge1 production via administration the precursor essential fatty acid studied the effect capsules day evening primrose oil epo the manifestations patients received two week course placebo thereafter received epo for weeks and patients received placebo the weather worsened the placebo group experienced significantly more attacks than the epo group visual analogue scales assessing the severity attacks and coldness hands improved the epo group changes were seen either group hand temperatures and cold challenge plethysmography blood tests showed some antiplatelet effects the drug conclusion patients receiving epo benefited symptomatically this was not matched however any change objective assessment blood flow although changes platelet behaviour and blood prostanoids were observed
86013102 vascular spasm the hands and vibration trauma prevention the only therapy
85284526 vital capillary microscopic examination and transcutaneous po2 measurements intravenous prostaglandin infusion the ability single application micrograms alprostadil pge1 mean therapeutic dose microgram body weight cause changes capillary microscopy parameters and tcpo2 was investigated open study patients with peripheral arterial occlusive disease fontaine stage women and men average age and years respectively capillary microscopy investigations and oxygen tension measurements were carried out before and immediately after infusion pge1 solution laevulose using intra individual comparison pge1 led increase the number erythrocyte filled capillaries per mm2 improvement the initial condition the capillaries evaluated according fagrell and significant increase the tcpo2 whereas haemodynamic changes occurred all after laevulose these findings substantiate the view that pge1 also effective when applied intravenously distal from the arterial occlusion
86042317 use superficial electric stimulation factor preventing marked decrease skin temperature various diseases the peripheral blood vessels
86037006 transthoracic endoscopic sympathectomy
86030336 nifedipine and alpha adrenergic blockade raynaud phenomenon the efficacy nifedipine and prazosin the treatment raynaud phenomenon was assessed prospective double blind randomized cross over trial patients each patient received one week nifedipine tid one week prazosin tid and weeks placebo nifedipine was shown effective reducing both the frequency and the severity raynaud phenomenon whereas prazosin was ineffective before initiation therapy the patients pressor responses the intravenous alpha agonist phenylephrine were assessed the basal state min after oral nifedipine and min after oral prazosin the shift the right the log dose vasopressor response curves phenylephrine was similar with nifedipine and prazosin
86014938 raynaud phenomenon arterial occlusive disease hands with arterial occlusive disease systolic blood pressure all fingers was measured photoelectric plethysmography the correlation digital pressures with the presence raynaud phenomenon and angiographic evidence organic obstruction was studied digital pressures were significantly lowered the fingers with cold sensitivity fingers without raynaud phenomenon normal finger pressures were measured digital blood pressures were always normal fingers with obstruction only one side and through the finger the clinical significance measurement digital blood pressure arterial occlusive disease discussed
86003278 evaluation finger systolic pressure response local cooling the diagnosis primary raynaud phenomenon finger systolic pressure fsp response local cooling has been evaluated diagnostic test females with primary raynaud phenomenon prp the mean fsp degrees and degrees was significantly lower the patients than age and sex matched controls but there was large overlap the individual responses diagnostic sensitivity fsp degrees was only increasing the sensitivity the test lowered the specificity the number false positives rose this also reduced the predictive value for positive test diagnostic test prp individuals the measurement fsp appears limited value except severe cases when complete vessel closure often occurs measurement fsp will classify groups correctly and this objective physiological measure raynaud phenomenon may have place group comparisons
85279606 anticytoskeletal autoantibodies the connective tissue diseases the sera patients with connective tissue diseases were studied for the presence anticytoskeletal antibodies using indirect immunofluorescence method ptk2 cells fixed with paraformaldehyde and digitonin were used substrate antibodies intermediate filaments were detected sera polymyositis dermatomyositis systemic sclerosis rheumatoid arthritis and systemic lupus erythematosus patients and normal sera high titers these antibodies which were igm were present patients and normal sera antibodies microfilaments were present patients sera and absent all control sera these antibodies were igm igg the switch from igm igg antibody was observed patient igg antibody the spindle poles and midbody mitotic cells was present the serum patient with the crest syndrome calcinosis raynaud phenomenon esophageal dysmotility sclerodactyly telangiectasias antibodies intermediate filaments and microfilaments occur commonly the connective tissue diseases particularly and are not detected with substrates fixation methods used routine antinuclear antibody testing
85304976 nailfold capillary microscopy essential mixed cryoglobulinemia report several cases nailfold capillaries were examined eight patients with essential mixed cryoglobulinemia two patients disclosed marked abnormality these patients had raynaud phenomenon four patients with raynaud phenomenon disclosed normal capillary patterns thus microvascular pathology essential mixed cryoglobulinemia not related raynaud phenomenon
85270094 evaluation the patient with raynaud phenomenon idiopathic raynaud phenomenon raynaud disease very common among young women thorough history and physical examination are the keys determining the extent diagnostic workup otherwise normal and asymptomatic young woman with vasospastic attacks involving symmetric aspects the digits cbc urinalysis chest film and esr are recommended cost effective workup these studies are negative the disease probably benign history physical findings consistent with collagen vascular disease obstructive arterial disease carpal tunnel thoracic outlet syndrome should lead selected diagnostic tests men persons with onset vasospastic attacks after age and those with severe disease trophic changes the digits deserve more comprehensive workup screen for underlying causes
85231878 asymptomatic primary biliary cirrhosis progress report long term follow and natural history thirty six patients presenting with asymptomatic primary biliary cirrhosis have been followed for median period extending previously reported median follow study life table survival analysis indicates that the overall survival this subgroup patients with primary biliary cirrhosis continues remain similar that the general population over this period patients developed symptoms and patients died from liver disease patients remained asymptomatic state portal granulomas initial liver biopsy were the only finding that correlated with normal survival and continued asymptomatic state contrast associated autoimmune disorders thyroiditis sicca syndrome crst syndrome raynaud phenomenon correlated with decreased survival other clinical laboratory histologic features correlated with survival the development symptoms this extended follow study median indicates that many patients with asymptomatic primary biliary cirrhosis have benign outcome although developed signs symptoms progressive disease variable times from presentation the group survival remained similar the general population
86037124 double blind placebo controlled crossover randomized trial diltiazem raynaud phenomenon report the results double blind placebo controlled crossover randomized study the calcium channel blocking agent diltiazem the treatment raynaud phenomenon our results showed significant reduction both frequency and duration attacks vasospasm the hands there was detectable difference response between patients with primary and those with secondary raynaud phenomenon our study supports the use calcium channel blocking agents the treatment intermittent digital vasospasm
85268665 hemorheological hemocoagulation and photoplethysmographic changes induced the administration pentoxifylline patients with raynaud disease day per pentoxyphyllin administered for day brought about improvement symptomatology and photoplethysmographic readouts under base conditions and following the cooling test out females suffering from raynaud disease these results may explained improved microcirculation flow resulting from increased erythrocyte filterability and decrease fibrinogenemia
86045391 the vibration syndrome
86016538 anti centromere antibody biological marker the crest syndrome distinct from scleroderma using hep2 cells study antinuclear antibodies has resulted the discovery the anti centromere antibody which thought separate the crest syndrome from progressive systemic sclerosis scleroderma this antibody seems exceptional healthy subjects and are patients with connective tissue diseases except for scleroderma has also been found crest syndrome associated with other diseases such primary cirrhosis and neoplasias our study the sensitivity the anti centromere antibody was and its specificity which shows that worth looking for