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86144424 drug therapy vasculitis with prostaglandins
86097605 raynaud syndrome diagnosis and therapy
86028972 the blood supply fingers during raynaud attack comparison laser doppler flowmetry with other techniques responses combined body and finger cooling were recorded laser doppler flowmetry xenon washout and strain gauge plethysmography patients seven patients with primary raynaud phenomenon and with generalized scleroderma and nine healthy warm handed subjects finger systolic blood pressure decreased zero the patients after body and finger cooling measured with strain gauge plethysmography with the laser doppler flowmeter low positive blood pressure was registered two patients the duration raynaud attack was found vary from greater than minutes observed the laser doppler flowmeter xenon washout from the fingertips during zero blood flow situation insignificantly deviated from the washout during vascular occlusion concluded that the elicitation and duration raynaud phenomenon could clearly observed laser doppler flowmetry the zero blood flow observed laser doppler flowmetry could confirmed xenon washout and cases the laser doppler flowmetry seemed more sensitive than the strain gauge extremely low blood flow values
86051213 anticentromere antibody immunological marker subset systemic sclerosis our clinical and immunological studies cases systemic sclerosis raynaud disease and other connective tissue diseases centered the diagnostic and prognostic significance anticentromere antibodies aca the aca occurred patients with acrosclerosis four patients with raynaud disease but none patients with diffuse scleroderma transitional form acrosclerosis diffuse scleroderma cases other connective tissue diseases the aca positive patients had contracture immobilization the fingers the indurations and indurative oedema were confined fingers and usually other types ana were detected however systemic involvement and the course the disease were comparable aca negative and aca positive acrosclerosis patients the studies indicate that there subset acrosclerosis with minimal indurations confined the fingers and aca appears its serological marker propose use the term crest for this subset which date has not been exactly defined and regarded some authors synonymous with acrosclerosis
86103660 raynaud disease new therapeutic approach with ht2 receptors blocker
86029026 calcium channel blocking drugs part clinical applications ccb are diverse group drugs that bind specific glycoprotein receptors associated with the cell membrane that are most likely identical the voltage sensitive calcium channel inhibiting the influx calcium into myocardial pacemaker and conducting tissues and vascular smooth muscle these agents modify excitation contraction coupling muscle and electrical impulse transmission the heart the vasodilating and electrophysiologic actions these drugs have been harnessed for the treatment coronary vasospasm angina pectoris and supraventricular arrhythmias they also have great potential for the treatment hypertension cerebrovascular disorders and raynaud phenomenon their utility hypertrophic cardiomyopathy congestive heart failure myocardial preservation and primary pulmonary hypertension has not been convincingly established future second generation ccb may offer greater selectivity improved side effect profiles and even wider range actions
86025693 modulatory effect sera from scleroderma patients lymphocyte induced angiogenesis sera from patients with progressive systemic sclerosis were tested for the ability modify the angiogenic capability normal human mononuclear cells the sera from patients with acrosclerosis including the abortive form crest syndrome calcinosis raynaud phenomenon esophageal dysmotility sclerodactyly telangiectasias markedly enhanced this capability compared with sera from both healthy donors and patients with severe acrosclerosis and diffuse scleroderma the enhancing effect sera from patients with acrosclerosis decreased and disappeared cases where the patient acrosclerosis was chronic and severe thus this test may diagnostic value distinguishing various subgroups systemic sclerosis
86014952 thoracic outlet syndrome thoracic outlet syndrome produced many aetiopathogenic factors that compress stretch the brachial plexus the subclavian region clinical aspects diagnostic procedure and instrumental examinations are discussed treatment programme should based the many factors causing the syndrome most patients however derive benefit from suitable exercise programme and this recommended initial approach all cases
85284572 diagnosis and therapy the acral ischemia syndrome
86099272 evaluation panergon therapy raynaud syndrome within the scope progressive scleroderma patients with progressive systemic sclerosis with raynaud phenomenon papaverin hydrochloride retard panergon therapy was used the average age females and male was years panergon therapy lasted for weeks the daily dose being for the evaluation the treatment instrumental methods were used radiometry for measuring thermal changes the hands capillaroscopy nailfold and doppler ultrasonic examination for measuring the circulation finger arteries increased temperature particularly the fingertips was found radiometric examination patients also observed the acceleration capillary flow speed patients the pulse wave finger arteries was markedly increased patients from the subjective point view the panergon therapy was judged successful patients was not necessary interrupt the treatment because unfavourable effects any case panergon therapy seems important step the treatment raynaud phenomenon progressive systemic sclerosis
86023696 digital pressure flow relationships subjects with raynaud phenomenon order determine whether subjects with raynaud phenomenon have altered digital hemodynamics the warm basal condition characterized the digital pressure flow relationships seven subjects with raynaud phenomenon and compared the results with age and sex matched control subjects digital pressure flow relationships were measured the use plethysmographic technique during passive elevation the arm normal subjects demonstrated positive finger systolic pressure zero flow mmhg indicative critical closing pressure however the closing pressure was significantly higher the subjects who had history raynaud phenomenon mmhg less than contrast there was significant difference found the conductance measured the slope the pressure flow relationship subjects with raynaud phenomenon demonstrated correlation between finger systolic pressure and critical closing pressure suggesting that these subjects may regulate arterial pressure through critical closing pressure mechanism
86022658 association between raynaud phenomenon and hearing loss forestry workers forestry workers using chain saws run the risk both vibration disease and noise induced hearing loss was reported that people with raynaud phenomenon occupational origin had more severe hearing loss than those without possibility confounding due age and duration noise exposure from the tools remained unsolved however matched pair case control study was conducted eliminate such confounding forestry workers operating chain saws bush cleaners and winches were investigated for men with raynaud phenomenon control was chosen from those unaffected whose age and operating hours for the tools were almost equal those the cases good matching was achieved for age and for total hours work with the tools the cases had higher median hearing threshold than the controls every frequency the difference was significant less than and khz and almost significant khz not equal according our classification the audiogram the cases had more advanced types noise induced hearing loss than did the controls thus association between raynaud phenomenon and hearing impairment forestry workers handling chain saws and other tools was found persist even after the effect age and exposure time was eliminated
85305914 decreased nailfold capillary density raynaud phenomenon reflection immunologically mediated local and systemic vascular disease nailfold capillary patterns were studied patients with raynaud phenomenon including patients wih and without connective tissue disease ctd capillary density was decreased patients with sclerodactyly digital ulcers tuft resorption and telangiectasia compared with patients without these symptoms addition inverse relationship was found between the severity first presentation graded photoelectric plethysmography during cooling and the capillary density patients with ctd less than the total group patients nailfold capillary density was inversely related organ system involvement less than decreased nailfold capillary density was observed particular patients with oesophageal hypomotility and patients with chest rays compatible with interstitial fibrosis factors supposedly involved the pathogenesis vascular changes ctd the presence autoantibodies increased levels circulating immune complexes and increased levels acute phase reactants were all associated with decreased number nailfold capillaries conclude that loss nailfold capillaries observed microscopy reflection local and systemic vascular disease
86243519 interpersonal stress and style predictors biofeedback relaxation training outcome preliminary findings although the data base describing clinical outcome following biofeedback relaxation training accumulating there have been relatively few attempts predict short term outcome and even fewer for long term outcome significant short term outcome predictors have been identified and they often allude the level psychological distress major factor affecting outcome investigate further the role psychological variables outcome prediction this project presents preliminary findings that demonstrate the relationship involving interpersonal psychological stress interpersonal style behavior and outcome with very heterogeneous group patients measures interpersonal style behavior were used discriminate correctly cases outcome the month postadmission evaluation with more homogeneous group having somatic disorders alone headache raynaud etc the accuracy prediction months was measures were capable predicting long term outcome with accuracies even moderately greater than chance the results indicate that style interpersonal behavior managerial dependent and lesser extent interpersonal stress predictive short term outcome following biofeedback relaxation training individuals who tend like responsibility and who are more executive and independent generally benefited more than doubtful obedient and depressed individuals while the resulting prediction rates were only slightly more accurate than mmpi and subscales alone the procedures provide additional information regarding the personality characteristics successful and unsuccessful biofeedback clients and may also provide the clinician with information regarding treatment choice biofeedback provided adjunct psychotherapy
85289491 fractionation and initial characterization the kinetochore from mammalian metaphase chromosomes have partially isolated the kinetochore and associated centromeric structures from mammalian metaphase chromosomes human autoantibodies from scleroderma crest calcinosis raynaud phenomenon esophageal dysmotility sclerodactyly telangiectasia patients were used immunofluorescent probes monitor fractionation the procedure includes digestion total chromosomal dna with micrococcal nuclease dehistonization with heparin and dissociation the remaining material with detergent and urea used density gradient metrizamide obtain enriched fraction stained material kinetochore when examined electron microscopy the kinetochore fraction seen contain numerous small immunoperoxidase positive masses which are morphologically similar the centromere kinetochore region intact metaphase chromosomes the particulate fraction that contains kinetochore components represents less than total chromosomal proteins and contains less than total dna two polypeptides and were identified kinetochore antigens immunoblotting with crest antiserum this paper discuss the distribution these kinetochore polypeptides with the associated centromeric chromatin
86051192 differences red cell behaviour between patients with raynaud phenomenon and systemic sclerosis and patients with raynaud disease the filterability and electrophoretic mobility erythrocytes from patients with systemic sclerosis and raynaud phenomenon were studied and compared with the findings from patients with raynaud disease and normal controls red blood cells from patients with systemic sclerosis and raynaud phenomenon were less filterable less than and had decreased electrophoretic mobility less than compared with erythrocytes from patients with raynaud disease and the controls there was significant difference between the values from the patients with raynaud disease and the controls these results indicate that measurement erythrocyte filterability and electrophoretic mobility may useful the differentiation patients with raynaud disease who have underlying collagen disease from those who have raynaud phenomenon association with systemic sclerosis
86091407 raynaud disease
86045434 doppler ultrasonic investigation raynaud phenomenon effect temperature blood velocity have used spectral analysis signals from pulsed range gated doppler ultrasonic instrument make quantitative measurements arterial blood flow velocity the hands normal subjects and persons with raynaud phenomenon measured the peak velocity during the cardiac cycle and the time integral the velocity signal over the cardiac cycle this latter parameter gives sensitive indication the degree vasoconstriction response cold our preliminary results based findings subjects suggest that doppler ultrasound can differentiate persons with raynaud phenomenon from normal subjects
86039531 sociomedical significance and prognosis the acral ischemia syndrome raynaud syndrome