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86047872 corticosteroid therapy associated with ischemic necrosis bone systemic lupus erythematosus this prospective study percent patients with systemic lupus erythematosus sle had ischemic necrosis bone sites all but two the patients had multiple sites involvement with hips knees and shoulders affected decreasing order frequency demographic clinical and laboratory features were comparable patients with and without ischemic necrosis bone except for cushingoid changes percent the patients with ischemic necrosis bone versus four percent the patients without ischemic necrosis bone less than the duration steroid therapy total cumulative steroid dose and the mean daily prednisone dose for the first one three six and months therapy were not significantly different between the two groups mean daily prednisone dose for the highest single month well the highest consecutive three six and months therapy was significantly higher patients with ischemic necrosis bone the mean daily dose prednisone for the highest month therapy was greater than per day percent and greater than per day all patients with ischemic necrosis bone patients with ischemic necrosis bone there was statistically significant correlation between higher mean prednisone dose all time intervals and increased number bony sites involved lower mean dose prednisone was required produce ischemic necrosis bone patients with raynaud phenomenon
86047867 hypothenar hammer syndrome form reversible raynaud phenomenon hypothenar hammer syndrome reversible yet uncommonly encountered cause raynaud phenomenon characteristic findings include coldness the dominant hand male absence triphasic color change and thumb involvement and occupational recreational use the hand hammer angiography demonstrates the specific findings irregularity occlusion the ulnar artery downstream occluded proper digital arteries and intraluminal emboli the sites distal obstruction vulnerable area traumatic occlusion provided the anatomic relationship the superficial branch the ulnar artery the hamate bone and the palmar aponeurosis pathologic studies separate the hypothenar hammer syndrome from clinically similar vasculitis important recognize the hypothenar hammer syndrome distinct entity because treatment curative and consists resection the affected vascular segment and avoidance the aggravating conditions
86024342 the clinical significance periodic acid schiff positive deposits cuticle proximal nail fold biopsy specimens vivo capillary microscopic findings and proximal nail fold biopsy specimens from patients with various connective tissue diseases idiopathic raynaud phenomenon and non connective tissue diseases were studied periodic acid schiff positive serous cuticular deposits were not specific the group patients with connective tissue disease generally the severity deposits correlated with the severity the vivo capillary microscopic pattern but not with disease severity duration the finding these cuticular deposits may help identify those patients with idiopathic raynaud phenomenon who are risk develop connective tissue disease
86011790 vascular reactivity and panic attacks
86049577 multiclinic placebo controlled double blind study prostaglandin raynaud syndrome prostaglandin alprostadil prostin sterile solution pge1 was evaluated patients with raynaud syndrome multiclinic placebo controlled double blind study total patients with either primary raynaud disease raynaud disease secondary systemic sclerosis were randomly assigned receive either pge1 administered intravenously min for hours placebo administered the same manner the frequency and severity raynaud attacks were then monitored for four weeks use clinic questionnaires and patients daily diaries haemodynamic assessments included measurements skin temperature and the finger systolic pressure response localised digital cooling immediately after the infusion the overall symptoms both the pge1 and the placebo group showed marked improvement four weeks after infusion some cases values had not returned pretreatment levels there was however marked benefit pge1 treatment over that placebo although pge1 significantly increased skin temperature during and immediately after infusion the effect did not persist two and four week follow evaluations the finger systolic pressure response localised digital cooling degrees increased more the pge1 treated group than the placebo treated group but the difference was not statistically significant there was difference ulcer healing between the two treatment groups these results failed substantiate earlier open label reports that hour intravenous infusion pge1 patients with raynaud syndrome produced significant clinical benefit
86051248 anti nuclear rnp antibodies two sisters two sisters with clinical elements mixed connective tissue disease were found have anti nuclear rnp nrnp antibodies these antibodies were not found the six other family members examined the sisters had inherited identical hla haplotype bw61 cw3 dr1 from their mother who had had raynaud phenomenon for several years analysis peripheral lymphocyte subsets the patients and their immediate relatives showed decreased okt positive cells one the patients and increased okt positive cells both patients their father and their brother resulting lower okt okt ratios these members the family this the third description the familial occurrence anti nrnp antibodies and adds further evidence for the implication genetic factors the development anti nrnp antibodies
86024341 juvenile linear scleroderma associated with serologic abnormalities investigated juvenile cases linear scleroderma for the presence systemic disease and serologic abnormalities thirteen patients had antinuclear antibodies ana titers greater rheumatoid factor titers greater than equal was detected seven patients tested five whom also had ana two five patients with ana and rheumatoid factor had systemic diseases such nephritis and raynaud phenomenon one patient with ana developed typical dermatomyositis consequently patients with linear scleroderma may some risk for developing systemic collagen vascular diseases initial presentation patients with linear scleroderma should give complete history and receive thorough physical examination well undergo laboratory evaluations for the presence ana and rheumatoid factor long term observation with periodic reevaluation appropriate for many members this group
86052153 platelet sensitivity prostacyclin analogue systemic sclerosis vascular prostacyclin pgi2 regulates platelet function and blood flow systemic sclerosis there increased platelet aggregation but information available the platelet pgi2 relationship evaluated platelet sensitivity pgi2 analogue zk36374 patients and controls the percentage inhibition was measured two doses zk36374 with saline giving the baseline the group zk36374 produced percentage inhibition compared control value and percentage inhibition the group and the controls patients treated with either prostaglandin nifedipine the sensitivity approached normal these data suggest that platelets are less sensitive the inhibitory effect pgi2 this may contribute the vascular lesions other cells are resistant the effects pgi2 and our findings support this picture cellular resistance
86044804 cardiac involvement mixed connective tissue disease fatal case scleroderma combined with systemic lupus erythematosus year old black woman with cardiac failure angina pectoris and raynaud syndrome presented skin biopsy and barium studies established the diagnosis scleroderma progressive systemic sclerosis pss systemic lupus erythematosus sle was strongly suggested the results immunological studies and increasing severity renal failure because the possibility cardiomyopathy cardiac catheterization selective coronary angiography and right ventricular endomyocardial biopsy were carried out but failed show any histological features either sle pss the patient went into progressive renal failure despite immunosuppressive therapy and plasmapheresis and died consent for autopsy was refused final diagnosis mixed connective tissue disease mctd was made the salient features cardiac involvement sle pss and mctd are outlined
86001445 vibration white finger newly prescribed disease
86149708 disseminated essential telangiectasis the authors report their observation disseminated primary telangiectasia over fifteen years many results all negative have been necessary order eliminate subjacent auto immune affection caused the associated raynaud phenomenon attempts treatment using tetracyclin and ketoconazol have been thwarted failures
86122091 primary biliary cirrhosis associated with the crst syndrome
86115188 induced vasodilation home treatment for raynaud disease ten patients with raynaud disease treated themselves home using induced vasodilation times day every other day for treatment days the patients dressed indoor clothing immersed both hands warm tap water degrees for min while exposed naturally occurring ambient cold results pre and posttreatment cold exposures showed significant mean increase digital temperature degrees less than conditioning therapy appears effective feasible alternative drug surgical therapy
86092728 the combination repeated anesthetic bathing the cervico thoracic system and buflomedil analgesic therapy raynaud syndrome the arm
86083223 characteristics the peripheral and central hemodynamics vibration disease miners eastern siberia
86075826 reynaud phenomenon and entrapment neuropathies
86053679 thermographic examination occupational vasoneuroses
86000443 study white finger the gas industry men engaged breaking reinstating road surfaces are exposed vibration from mechanical tools view the lack epidemiological information vibration white finger such population survey was carried out identify the prevalence symptoms white finger sample men using these tools the gas industry and compare the prevalence with that found control group not occupationally exposed vibration altogether men the gas industry and men the control group were interviewed using questionnaire from which the presence absence white finger symptoms from all causes was noted the prevalence white finger was the group exposed vibration work compared with the control group the prevalence the former group when adjusted for age differences between the survey and control populations was but this difference did not reach statistical significance case the approach comparing prevalences white finger from all causes might have obscured any contributory effect vibration the prevalence white finger was examined relation the number years vibrating tools had been used this being the only measure exposure vibration available direct association was found between the prevalence symptoms and number years vibrating tools had been used view this and the absence significant excess white finger symptoms the group using vibratory tools the authors conclude that vibration white finger not special problem the gas industry abstract truncated words
86151053 raynaud syndrome pathophysiologic mechanisms diagnosis treatment