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86122748 indications for nailbed capillaroscopy raynaud phenomenon patients with raynaud phenomenon underwent nailfold capillaroscopy had suspected connective tissue diseases idiopathic raynaud disease and variety other diagnoses normal capillaroscopy fully consistent with raynaud disease pathological capillaroscopy with megacapillaries prompts suspicion underlying connective tissue disease the other abnormal capillaroscopies are suggestive raynaud phenomenon secondary one the numerous associated diseases and not rule out evolution connective disease waiting group the proposed simplified classification seems offer reasonably good discrimination the probability abnormal capillaroscopy increases with the age onset raynaud phenomenon but not insignificant younger patients the year old allen criterion years follow without signs underlying diseases such scleroderma etc disappointing and should discarded nailfold capillaroscopy non invasive procedure which useful any age
86027677 hypomagnesemia renal dysfunction and raynaud phenomenon patients treated with cisplatin vinblastine and bleomycin thirty men with metastatic germ cell cancer were treated with cisplatin administered intravenously days vinblastine and bleomycin week intervals for four six courses there was sequential fall serum magnesium less than with each course therapy the patients became hypomagnesemic and the median magnesium nadir was meq acute clinical effects the hypomagnesemia were observed the mean creatinine clearance declined from minute before therapy minute and the mean serum creatinine rose from after six courses therapy with minimum follow months the patients have clinical evidence raynaud phenomenon severity prior hypomagnesemia predicted increased risk raynaud phenomenon renal dysfunction hypomagnesemia and raynaud phenomenon are common chronic toxicities vinblastine bleomycin and cisplatin therapy
86124248 raynaud phenomenon following treatment with cytostatics
86143553 dermatopolymyositis and other connective tissue diseases review cases cases seen over years with mean years followup there were with polymyositis and with dermatomyositis and this complicated another connective tissue disease ctd primary had onset decade later than others and most severe myopathy occurred earliest symptoms were polyarthritis and raynaud phenomenon with frequent sicca syndrome the less than universal prevalence elevated muscle enzymes myopathic electromyography and abnormal muscle biopsy emphasizes the need for complete evaluation all cases improvement occurred overall including all given therapy low dose corticosteroids and the remainder who received high dose corticosteroids with added cytotoxics one quarter outcome was worse older patients and those where weakness exceeded months before diagnosis eight deaths were due myositis its therapy which also caused considerable morbidity malignancy cases was temporally related myositis half these cases
86101374 cl115 analogue prostaglandin peripheral circulatory effects single ascending doses administered transdermally normal subjects and patients with raynaud phenomenon the beneficial effects intra arterial intravenous infusion the prostanoid products anachridonic acid pge and prostacyclin pgi2 are well documented more recently analogue pge2 american cynamid has become available this substance absorbed transdermally from patch placed the skin placebo controlled trial the vasodilatory effect single incremental dosage mcg mcg and mcg was measured temperature humidity controlled laboratory normal subjects and patients with primary and secondary raynaud phenomenon the optimal dosage proved mcg the effect may last for hours higher dosage may associated with steal phenomenon
86101372 effects diltiazem occupational raynaud syndrome vibration disease open trial the therapeutic effect diltiazem calcium antagonist was conducted occupational raynaud syndrome vibration disease seventeen men with vibration disease were studied the mean age was years patient had cardiovascular disease primary and secondary cases raynaud phenomenon were excluded diltiazem 30mg orally times daily was given the patients for weeks before and after this treatment period evaluated the subjective symptoms items including raynaud phenomenon numbness hands and arms stiffness shoulder and neck and others and peripheral function cold water immersion test vibration and pain sensations for fingers tapping test and momentary grasp strength test and did laboratory blood tests variables the effective rates subjective symptoms evaluating the method steps and the peripheral function was and respectively the overall effectiveness diltiazem therapy was assessed collectively evaluating the changes subjective symptoms peripheral functions and the occurrence side effects side effects occurred during the treatment period thus the collective effectiveness diltiazem was conclusion diltiazem calcium antagonist can effective long term treatment patients with vibration disease
86101370 strain gauge plethsymography ischemic handsyndromes sixteen patients with ischemic handsyndromes strain gauge plethysmography was used noninvasive diagnostic test contrast arteriography was available for comparison these patients demonstrate the role for noninvasive test selecting patients with raynaud phenomenon asphyxia for arteriography
86100262 raynaud phenomenon relates hand tool vibration the workplace the current status raynaud phenomenon occupational origin occurs various workplace situations examined and discussed methods reducing the effects hand arm vibration exposure well the status current vibration standards also are discussed work practices guide recommended
86074723 upper dorsal sympathectomy over year period patients underwent procedures for upper dorsal sympathectomy usually with transaxillary approach but occasionally with anterior approach procedures male patients and those that were carried out the right side were most frequent there were few simultaneous procedures the extent sympathectomy included resection the lower half the stellate ganglion through the fourth thoracic ganglion the results were satisfying for patients with vasospastic disorders and hyperhidrosis and quite acceptable for those with causalgia and vaso occlusive disorders complication rates and the incidence postoperative horner syndrome were low there were prominent differences results among the various age groups addition female patients and those with bilateral procedures had less favorable results factors that did not appear affect results included technique surgical approach extent sympathectomy presence horner syndrome the addition other procedures current indications for upper dorsal sympathectomy include cases raynaud and buerger diseases refractory drug therapy causalgia vaso occlusive disorders and hyperhidrosis
86049490 vibration syndrome cutaneous and systemic manifestations jackhammer operator vibration syndrome which typically presents variant raynaud phenomenon has been characterized recently multisystem disorder the peripheral circulation nerves muscles and joints the sequelae the disorder are irreversible but most clinical evidence indicates that vibration injury completely reversible early intervention advanced occurred jackhammer operator his condition went unrecognized for more than years the clinical findings illustrate the broad spectrum pathologic abnormalities associated with and emphasize the need for increased physician awareness this disabling condition
86214338 therapeutic prospects and prostaglandins vascular pathology the discovery thromboxanes and prostacycline has opened new therapeutic approach vascular and thrombotic diseases aspirin longer considered antiaggregant drug but inhibitor cyclooxygenase which depending the dose may have effect platelets and the vessel thromboxane synthetase inhibitors and thromboxane receptor blockers represent new mode inhibition platelet activation therapeutic trials the vasodilator and antiaggregant prostacycline have been carried out obliterative arterial disease and raynaud syndrome with certain degree success the production stable analogue prostacycline and the manipulation the leukotrienes are the therapeutic hopes for the future
86296835 thermal feedback raynaud phenomenon secondary systemic lupus erythematosus long term remission target symptoms thermal feedback shows promise when applied raynaud phenomenon secondary systematic lupus erythematosus sle female subject was followed over year period that included initial training year follow and year follow peripheral circulation was initially very poor evidenced low basal fingertip temperatures and trophic lesions the fingernails intensive week training regimen thermal self regulation yielded evidence hand warming followed increase basal finger temperature reported vasospasms were markedly reduced and the lesions healed the ensuing weeks the year follow the skill was intact symptoms remained substantial remission throughout the year period during which the subject practiced somatic relaxation and hand warming without electronic feedback objective temperature measurement the year juncture yielded results similar the initial acquisition gradual manifestation control over the first days the subject also reported diminution vascular headache another symptom sle while much the biofeedback literature focused stress related disease research this kind affirms the value self regulatory technique illnesses whose causes are primarily physical
86179005 trial treatment severe raynaud phenomenon with prostacyclin pgi2 severe forms raynaud phenomenon are very disabling randomized single blind trial have evaluated the effects pgi2 natural compound with strong vasodilator and anti platelet activities patients presenting with raynaud phenomenon the patients received hour infusion either pgi2 doses min only the solvent glycine buffer all patients recorded the frequency and severity the attacks before and after treatment and the patients who received the solvent benefited from pgi2 infusion days later among the patients men women had underlying collagen disease the number attacks per week was initially mean the resulting impairment was pronounced scale radioimmunoassays prostaglandins showed strong increase keto pgf1 alpha levels during the infusion without changes thromboxane levels significant less than reduction was observed the number attacks per week and impairment average after pgi2 but not after the buffer improvement after pgi2 lasted from months and all but one patient regarded the treatment effective long term despite undesirable side effects flush hypotension which occurred regularly during pgi2 infusion all patients with ulcerations the finger tips these healed more rapidly after pgi2 concluded that spite immediate discomfort pgi2 hour infusions seems value the treatment severe raynaud phenomenon
86053892 the biochemical pharmacology thromboxane synthase inhibition man selective inhibitors thromboxane synthase have two theoretical advantages over inhibitors the cyclooxygenase enzyme potential antithrombotic compounds first they not prevent formation prostacyclin platelet inhibitory vasodilator compound coincident with inhibiting thromboxane biosynthesis second the prostaglandin endoperoxide substrate that accumulates the platelet the presence thromboxane synthase inhibition may donated endothelial prostacyclin synthase the site platelet vascular interactions endoperoxide steal selective inhibition thromboxane biosynthesis coincident with enhanced prostacyclin formation vivo has been observed after administration these compounds man despite these attractive features and the efficacy these compounds diverse short term animal preparations thrombosis investigations their efficacy human disease have proven disappointing this may reflect the importance thromboxane the diseases that have been investigated alternatively the lack drug efficacy may have resulted from either incomplete suppression thromboxane biosynthesis and substitution for the biological effects thromboxane prostaglandin endoperoxides during long term dosing studies given that selective inhibition thromboxane formation can approached with aspirin the particular value these compounds dependent enhancing prostacyclin formation aspirin inhibits thromboxane dependent platelet activation but many platelet agonists are likely act concert vivo and prostacyclin inhibits platelet aggregation induced both thromboxane dependent and thromboxane independent mechanisms test the hypothesis that thromboxane synthase inhibitors are efficacious human disease compounds longer duration action are required combination with antagonists the prostaglandin thromboxane receptor may necessary reveal their full beneficial action
86241261 localized real time blood flow measurements novel method for real time localized flow measurements applied blood flow human fingers results for arterial and venous flow normal subjects and patients with abnormal blood circulation are presented effects blood flow regulation the autonomic nervous system have been observed stricture the digital arteries could clearly demonstrated patient with raynaud phenomenon experimental signals due pulsatile flow model system can simulated quantitative way the calibration however depends the actual spin spin relaxation time and the shape the pulsatile flow time curve due these limitations the volume flow rate can measured with relative error approximately
86067805 minimal etiological evaluation raynaud phenomenon cases the efficacy minimal aetiological investigation program was tested population with raynaud phenomenon the program had been devised fulfill the following criteria non invasive simple and relatively cheap methods capable detecting systemic scleroderma early stage these methods turned out physical examination screening for antinuclear antibodies capillaroscopy and radiography the hands and chest after investigations which addition the minimal program included exploration the digestive and respiratory tracts heart kidneys articulations and eyes consecutive cases raynaud phenomenon were studied and divided into groups idiopathic secondary including cases collagen disease which were systemic scleroderma and suspected idiopathic pre collagen disease cases undetermined origin but not considered idiopathic view clinical and paraclinical abnormalities non idiopathic raynaud phenomenon physical examination capillaroscopy and screening for antinuclear antibodies gave abnormal results the cases this figure was raised when radiography the hands and chest was added these examinations but the difference was not significant since non idiopathic raynaud phenomena could diagnosed physical examination capillaroscopy and screening for antinuclear antibodies suggested that all patients presenting with the phenomenon should subjected these three simple examinations negative results then dispense from supplementary investigations
86111056 non drug treatment for migraine headache with associated raynaud disease
86052150 joint mobility among university students iraq the prevalence joint hypermobility among university students aged years iraq has been determined from survey made the degree joint hypermobility was scored scale between and using the method described beighton his modification the carter and wilkinson scoring system joint hypermobility defined score out greater was found males and females the presence joint complaints ligamentous sprains flat feet raynaud phenomenon easy bruising high palate and varicose veins correlated well with joint hypermobility and were seen significantly more frequently students scoring out more than students scoring out less the right usually dominant side was significantly less mobile than the left side whatever the hypermobility score physique expressed body weight and height did not show any relation joint mobility
86050789 noninvasive evaluation cardiac dysrhythmias and their relationship with multisystemic symptoms progressive systemic sclerosis patients fifty three patients who had diffuse scleroderma and who had crest syndrome calcinosis raynaud phenomenon esophageal dysmotility sclerodactyly and telangiectasias were studied noninvasive procedures including resting electrocardiogram ecg continuous hour holter ecg monitoring mode echocardiography and dimensional echocardiography only patients had abnormalities such conduction defects supraventricular ventricular arrhythmias changes detected resting ecg contrast using holter monitoring the number conduction abnormalities seen increased from patients and transient changes increased from patients forty eight patients had ventricular arrhythmias with multiform ventricular premature beats pairs runs ventricular tachycardia patients and more runs ventricular tachycardia echocardiography detected asymmetric septal hypertrophy patients impaired ventricular function patients congestive cardiomyopathy mitral prolapse and pericardial effusion patients multiform and repetitive ventricular premature beats occurred more frequently patients with echocardiographic abnormalities but were also present patients who had normal findings echocardiographic examination cardiac involvement was not correlated with clinical variants scleroderma crest syndrome diffuse scleroderma nor with other signs and symptoms the disease thus cardiac involvement found much more frequently than would expected from clinical symptoms from results resting ecg alone therefore holter monitoring and echocardiography should included the routine workup patients who have scleroderma