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subtype INTEGER { chromosome (1) , map (2) , clone (3) , subclone (4) , haplotype (5) , genotype (6) , sex (7) , cell-line (8) , cell-type (9) , tissue-type (10) , clone-lib (11) , dev-stage (12) , frequency (13) , germline (14) , rearranged (15) , lab-host (16) , pop-variant (17) , tissue-lib (18) , plasmid-name (19) , transposon-name (20) , insertion-seq-name (21) , plastid-name (22) , country (23) , segment (24) , endogenous-virus-name (25) , other (255) } , name VisibleString , attrib VisibleString OPTIONAL } -- attribution/source of this name END--**********************************************************************---- NCBI Protein-- by James Ostell, 1990-- version 0.8----**********************************************************************NCBI-Protein DEFINITIONS ::=BEGINEXPORTS Prot-ref;IMPORTS Dbtag FROM NCBI-General;--*** Prot-ref ***********************************************--*--* Reference to a protein name--*Prot-ref ::= SEQUENCE { name SET OF VisibleString OPTIONAL , -- protein name desc VisibleString OPTIONAL , -- description (instead of name) ec SET OF VisibleString OPTIONAL , -- E.C. number(s) activity SET OF VisibleString OPTIONAL , -- activities db SET OF Dbtag OPTIONAL , -- ids in other dbases processed ENUMERATED { -- processing status not-set (0) , preprotein (1) , mature (2) , signal-peptide (3) , transit-peptide (4) } DEFAULT not-set }END --********************************************************************---- Transcription Initiation Site Feature Data Block-- James Ostell, 1991-- Philip Bucher, David Ghosh-- version 1.1---- ----********************************************************************NCBI-TxInit DEFINITIONS ::=BEGINEXPORTS Txinit;IMPORTS Gene-ref FROM NCBI-Gene Prot-ref FROM NCBI-Protein Org-ref FROM NCBI-Organism;Txinit ::= SEQUENCE { name VisibleString , -- descriptive name of initiation site syn SEQUENCE OF VisibleString OPTIONAL , -- synonyms gene SEQUENCE OF Gene-ref OPTIONAL , -- gene(s) transcribed protein SEQUENCE OF Prot-ref OPTIONAL , -- protein(s) produced rna SEQUENCE OF VisibleString OPTIONAL , -- rna(s) produced expression VisibleString OPTIONAL , -- tissue/time of expression txsystem ENUMERATED { -- transcription apparatus used at this site unknown (0) , pol1 (1) , -- eukaryotic Pol I pol2 (2) , -- eukaryotic Pol II pol3 (3) , -- eukaryotic Pol III bacterial (4) , viral (5) , rna (6) , -- RNA replicase organelle (7) , other (255) } , txdescr VisibleString OPTIONAL , -- modifiers on txsystem txorg Org-ref OPTIONAL , -- organism supplying transcription apparatus mapping-precise BOOLEAN DEFAULT FALSE , -- mapping precise or approx location-accurate BOOLEAN DEFAULT FALSE , -- does Seq-loc reflect mapping inittype ENUMERATED { unknown (0) , single (1) , multiple (2) , region (3) } OPTIONAL , evidence SET OF Tx-evidence OPTIONAL }Tx-evidence ::= SEQUENCE { exp-code ENUMERATED { unknown (0) , rna-seq (1) , -- direct RNA sequencing rna-size (2) , -- RNA length measurement np-map (3) , -- nuclease protection mapping with homologous sequence ladder np-size (4) , -- nuclease protected fragment length measurement pe-seq (5) , -- dideoxy RNA sequencing cDNA-seq (6) , -- full-length cDNA sequencing pe-map (7) , -- primer extension mapping with homologous sequence ladder pe-size (8) , -- primer extension product length measurement pseudo-seq (9) , -- full-length processed pseudogene sequencing rev-pe-map (10) , -- see NOTE (1) below other (255) } , expression-system ENUMERATED { unknown (0) , physiological (1) , in-vitro (2) , oocyte (3) , transfection (4) , transgenic (5) , other (255) } DEFAULT physiological , low-prec-data BOOLEAN DEFAULT FALSE , from-homolog BOOLEAN DEFAULT FALSE } -- experiment actually done on -- close homolog -- NOTE (1) length measurement of a reverse direction primer-extension -- product (blocked by RNA 5'end) by comparison with -- homologous sequence ladder (J. Mol. Biol. 199, 587) END--$Revision: 1000.1 $--**********************************************************************---- NCBI Sequence Analysis Results (other than alignments)-- by James Ostell, 1990----**********************************************************************NCBI-Seqres DEFINITIONS ::=BEGINEXPORTS Seq-graph;IMPORTS Seq-loc FROM NCBI-Seqloc;--*** Sequence Graph ********************************--*--* for values mapped by residue or range to sequence--*Seq-graph ::= SEQUENCE { title VisibleString OPTIONAL , comment VisibleString OPTIONAL , loc Seq-loc , -- region this applies to title-x VisibleString OPTIONAL , -- title for x-axis title-y VisibleString OPTIONAL , comp INTEGER OPTIONAL , -- compression (residues/value) a REAL OPTIONAL , -- for scaling values b REAL OPTIONAL , -- display = (a x value) + b numval INTEGER , -- number of values in graph graph CHOICE { real Real-graph , int Int-graph , byte Byte-graph } }Real-graph ::= SEQUENCE { max REAL , -- top of graph min REAL , -- bottom of graph axis REAL , -- value to draw axis on values SEQUENCE OF REAL }Int-graph ::= SEQUENCE { max INTEGER , min INTEGER , axis INTEGER , values SEQUENCE OF INTEGER } Byte-graph ::= SEQUENCE { -- integer from 0-255 max INTEGER , min INTEGER , axis INTEGER , values OCTET STRING }END--$Revision: 1000.1 $--**********************************************************************---- NCBI Sequence Collections-- by James Ostell, 1990---- Version 3.0 - 1994----**********************************************************************NCBI-Seqset DEFINITIONS ::=BEGINEXPORTS Bioseq-set, Seq-entry;IMPORTS Bioseq, Seq-annot, Seq-descr FROM NCBI-Sequence Object-id, Dbtag, Date FROM NCBI-General;--*** Sequence Collections ********************************--*Bioseq-set ::= SEQUENCE { -- just a collection id Object-id OPTIONAL , coll Dbtag OPTIONAL , -- to identify a collection level INTEGER OPTIONAL , -- nesting level class ENUMERATED { not-set (0) , nuc-prot (1) , -- nuc acid and coded proteins segset (2) , -- segmented sequence + parts conset (3) , -- constructed sequence + parts parts (4) , -- parts for 2 or 3 gibb (5) , -- geninfo backbone gi (6) , -- geninfo genbank (7) , -- converted genbank pir (8) , -- converted pir pub-set (9) , -- all the seqs from a single publication equiv (10) , -- a set of equivalent maps or seqs swissprot (11) , -- converted SWISSPROT pdb-entry (12) , -- a complete PDB entry mut-set (13) , -- set of mutations pop-set (14) , -- population study phy-set (15) , -- phylogenetic study eco-set (16) , -- ecological sample study gen-prod-set (17) , -- genomic products, chrom+mRNa+protein other (255) } DEFAULT not-set , release VisibleString OPTIONAL , date Date OPTIONAL , descr Seq-descr OPTIONAL , seq-set SEQUENCE OF Seq-entry , annot SET OF Seq-annot OPTIONAL }Seq-entry ::= CHOICE { seq Bioseq , set Bioseq-set } END--$Revision: 1000.1 $--**********************************************************************---- NCBI Sequence elements-- by James Ostell, 1990-- Version 3.0 - June 1994----**********************************************************************NCBI-Sequence DEFINITIONS ::=BEGINEXPORTS Bioseq, Seq-annot, Pubdesc, Seq-descr, Seqdesc, Numbering, Heterogen, Seq-hist, GIBB-mol;IMPORTS Date, Int-fuzz, Dbtag, Object-id, User-object FROM NCBI-General Seq-align FROM NCBI-Seqalign Seq-feat FROM NCBI-Seqfeat Seq-graph FROM NCBI-Seqres Pub-equiv FROM NCBI-Pub Org-ref FROM NCBI-Organism BioSource FROM NCBI-BioSource Seq-id, Seq-loc FROM NCBI-Seqloc GB-block FROM GenBank-General PIR-block FROM PIR-General EMBL-block FROM EMBL-General SP-block FROM SP-General PRF-block FROM PRF-General PDB-block FROM PDB-General;--*** Sequence ********************************--*Bioseq ::= SEQUENCE { id SET OF Seq-id , -- equivalent identifiers descr Seq-descr OPTIONAL , -- descriptors inst Seq-inst , -- the sequence data annot SET OF Seq-annot OPTIONAL }--*** Descriptors *****************************--*Seq-descr ::= SET OF SeqdescSeqdesc ::= CHOICE { mol-type GIBB-mol , -- type of molecule modif SET OF GIBB-mod , -- modifiers method GIBB-method , -- sequencing method name VisibleString , -- a name for this sequence title VisibleString , -- a title for this sequence org Org-ref , -- if all from one organism comment VisibleString , -- a more extensive comment num Numbering , -- a numbering system maploc Dbtag , -- map location of this sequence pir PIR-block , -- PIR specific info genbank GB-block , -- GenBank specific info pub Pubdesc , -- a reference to the publication region VisibleString , -- overall region (globin locus) user User-object , -- user defined object sp SP-block , -- SWISSPROT specific info dbxref Dbtag , -- xref to other databases embl EMBL-block , -- EMBL specific information create-date Date , -- date entry first created/released update-date Date , -- date of last update prf PRF-block , -- PRF specific information pdb PDB-block , -- PDB specific information het Heterogen , -- cofactor, etc associated but not bound source BioSource , -- source of materials, includes Org-ref molinfo MolInfo } -- info on the molecule and techniques--******* NOTE:--* mol-type, modif, method, and org are consolidated and expanded--* in Org-ref, BioSource, and MolInfo in this specification. They--* will be removed in later specifications. Do not use them in the--* the future. Instead expect the new structures.--*--***************************--********************************************************************---- MolInfo gives information on the-- classification of the type and quality of the sequence---- WARNING: this will replace GIBB-mol, GIBB-mod, GIBB-method----********************************************************************MolInfo ::= SEQUENCE { biomol INTEGER { unknown (0) , genomic (1) , pre-RNA (2) , -- precursor RNA of any sort really mRNA (3) , rRNA (4) , tRNA (5) , snRNA (6) , scRNA (7) , peptide (8) , other-genetic (9) , -- other genetic material genomic-mRNA (10) , -- reported a mix of genomic and cdna sequence cRNA (11) , -- viral RNA genome copy intermediate other (255) } DEFAULT unknown , tech INTEGER { unknown (0) , standard (1) , -- standard sequencing est (2) , -- Expressed Sequence Tag sts (3) , -- Sequence Tagged Site survey (4) , -- one-pass genomic sequence genemap (5) , -- from genetic mapping techniques physmap (6) , -- from physical mapping techniques derived (7) , -- derived from other data, not a primary entity concept-trans (8) , -- conceptual translation seq-pept (9) , -- peptide was sequenced both (10) , -- concept transl. w/ partial pept. seq. seq-pept-overlap (11) , -- sequenced peptide, ordered by overlap
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